An important type of research on informed consent involves empirically testing interventions designed to improve the consent process. Here we report on the experience of eight teams that conducted research involving interventions designed primarily to impact one of three categories: decision-making, knowledge, and the therapeutic misconception. Comments © The Hastings Center. Reprinted by Permi...

Background: Although QT prolongation is associated with increased risk of torsade de pointes (TdP), the precise relationship is not well defined. Aim: To evaluate the performance of a QT nomogram in assessing the risk of TdP from QT– RR combinations. Design: Systematic review. Methods: We systematically searched MEDLINE/ EMBASE for cases of drug-induced TdP. Controls were patients taking non-ca...

Oxidative stress is believed to be an important factor in the development of age-related diseases, and studies in lower organisms have established links between oxidative stress tolerance and longevity. We have hypothesized that aging is associated with a reduced ability to mount acute host defenses to oxidant injury, which increases the vulnerability of aged cells to stress. We tested this hyp...

Increasing globalization is thought to be impacting business communications around the world (e.g. Connor, 2004). To assess possible impacts in one developing country, we examine contemporary written business communications in Turkey. So far so good. Now for the Move 3 (Method etc). So far they have reduced their long methods section to the following summary: The primary data used consist of ap...

The 2013 European Conference on Machine Learning and Principles and Practice of Knowledge Discovery in Databases (ECMLPKDD) was held in Prague, September 2013. Following the long-standing tradition of the series, it brought together researchers in Machine Learning and Data Mining for an exciting program of cutting-edge research results, aiming in particular at a cross-fertilization between thes...

Sharing of research data has begun to gain traction in many areas of the sciences in the past few years because of changing expectations from the scientific community, funding agencies, and academic journals. National Science Foundation (NSF) requirements for a data management plan (DMP) went into effect in 2011, with the intent of facilitating the dissemination and sharing of research results....

One expected consequence of increased transparency surrounding clinical trials is that journals will experience a significant growth in the number of manuscript submissions from industry-sponsored research, particularly manuscripts reporting the results of early-phase research. This increase could be substantial since, until recently, about 90% of Phase I studies and 60% of Phase II studies wer...

We describe a physical and logical layout analysis algorithm, which is applied to segment and label online medical journal articles (regular HTML and PDF-Converted-HTML files). For these articles, the geometric layout of the Web page is the most important cue for physical layout analysis. The key to physical layout analysis is then to render the HTML file in a Web browser, so that the visual in...

• Work schedule during pregnancy and spontaneous abortion. • Genetic evaluation of stillbirth in United States holsteins using a sirematernal grandsire threshold model. • Combining internal and external validation data to correct for exposure misclassification: A case study. • Activation of 5-HT1A receptors in the paragigantocellularis lateralis decreases shivering during cooling in the conscio...