Dihydrofolate reductase (EC 1.5.1.3) is a key enzyme in the folate biosynthetic pathway. Information regarding key residues in the dihydrofolate-binding site of Mycobacterium avium dihydrofolate reductase is lacking. On the basis of previous information, Asp31 and Leu32 were selected as residues that are potentially important in interactions with dihydrofolate and antifolates (e.g. trimethoprim...

The k-fold clique transversal problem is to locate a minimum set of vertices of a graph such that every maximal clique has at least k elements of. The maximum h-colourable subgraph problem is to nd a maximum subgraph of a graph which is h-colourable. We show that the k-fold clique transversal problem and the maximum h-colourable subgraph problem are polynomially solvable on balanced graphs. We ...

Adenylosuccinate synthetase governs the first committed step in the de novo synthesis of AMP. Mutations of conserved residues in the synthetase from Escherichia coli reveal significant roles for Val(273) and Thr(300) in the recognition of l-aspartate, even though these residues do not or cannot hydrogen bond with the substrate. The mutation of Thr(300) to alanine increases the K(m) for l-aspart...

In machine learning, the k value in k-fold cross-validation method significantly affects performance of created model. studies that have been done, is usually taken as five or ten because these two values are thought to produce average estimates. However, there no official rule. It has observed few carried out use different training models. this study, a evaluation was performed on IncRNA-disea...

Breast cancer is the second most common after lung and one of main causes death worldwide. Women have a higher risk breast as compared to men. Thus, early diagnosis with an accurate reliable system critical in treatment. Machine learning techniques are well known popular among researchers, especially for classification prediction. An investigation was conducted evaluate performance malignant tu...

In a systematic effort to identify a potent antiproliferative agent, four complexes of vanadium containing maltol and deferiprone ligands were synthesized and evaluated for their cytotoxic activity against five human and animal cancer cell lines, including human breast cancer cells (MCF-7), human cervix epithelial carcinoma (HeLa), human colon cancer cell line (HT-29), human leukemia cell line ...

For any integer n>2, the n-fold cyclic branched cover M of an alternating prime knot K in 3-sphere determines K, meaning that if ′ is a not equivalent to then its cannot be homeomorphic M.

A sequence (xn)n=1? on the torus T exhibits Poissonian pair correlation if for all s>0,limN???1N#{1?m?n?N:|xm?xn|?sN}=2s. It is known that this condition implies equidistribution of (xn). We generalize result to four-fold differences: s>0 we havelimN???1N2#{1?m,n,k,l?N{m,n}?{k,l}:|xm+xn?xk?xl|?sN2}=2s then equidistributed. This notion generalizes higher orders, and any k show a exhibiting 2k-fo...