AIM The aim of the study was to determine the potential for K(V)1 potassium channel blockers as inhibitors of human neoinitimal hyperplasia. METHODS AND RESULTS Blood vessels were obtained from patients or mice and studied in culture. Reverse transcriptase-polymerase chain reaction and immunocytochemistry were used to detect gene expression. Whole-cell patch-clamp, intracellular calcium measu...

This paper describes two approaches for the simultaneous identification of the coulomb and viscous parameters in kinematical joints. One is a time-domain method (TDM) and the other is a frequency-domain method (FDM). Simulation shows that both of the two methods have good performances in identifying friction at high SNR (90dB). But at low SNR (20dB), the estimation accuracy of the frequency-dom...

In a recent paper by Wu [1] the three-point correlation of the q-state Potts model on a planar graph was related to ratios of dual partition functions under fixed boundary conditions. It was claimed that the method employed could straightforwardly be applied to higher correlations as well; this is however not true. By explicitly considering the four-point correlation we demonstrate how the appe...

Fig. 1. Omnidirectional energy spectrum E(k) versus wavenumber k, computed from Eqs. (9)-(11), for the case A = 0:7, = 1, varying the rotation rate = 0; 10; 100. There is a smooth transition from the Komogorov`? 5=3' case = 0 to a spectrum = 100 that approaches a ` ? 2' form. Spontaneous breaking of reeexional symmetry in real quasi-two-dimensional turbulence: stochastic traveling waves and hel...

Alterations in the plasma water sodium concentration ([Na+]pw) result from changes in the total exchangeable sodium (Na e), total exchangeable potassium (K e), and total body water (TBW). The empirical relationship between the [Na+]pw and Na e, K e, and TBW was originally demonstrated (Edelman IS, Leibman J, O'Meara MP, and Birkenfeld LW. J Clin Invest 37: 1236-1256, 1958), where [Na+]pw = 1.11...

for 0 ^ x ^ 1, with initial condition y(x) 0) = 0 and end conditions y(0, t) = 1, 2/(1, i) = 0. Here x is position and t is time. The problem as stated is a nondimensional version of a heat-conduction problem in which a fixed temperature is suddenly applied to one end of an initially cold bar. Other diffusion problems involving impulsive boundary conditions may require a more complicated descri...

OBJECTIVE To assess the reliability and validity of the EuroQol (EQ-5D) for osteoarthritis of the knee (OA knee). METHODS Eighty-two patients with OA knee were asked to complete on two occasions, separated by 1 week, the EQ-5D, the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index and the 36-item short form of the Medical Outcomes Study (SF-36). RESULTS In this patient ...

An integral formulation for heat conduction problems in non-homogeneous media has recently been proposed in [1]. The goal of this communication is to revisit and clarify two key features of the formulation of [1]. First, the contention that the integral equation formulation proposed in [1] does not possess the desired boundary-only character is made and substantiated; it is shown in particular ...