Human cytomegalovirus (HCMV) is a leading cause of morbidity and mortality in immunocompromised hosts. In immunocompetent hosts, HCMV is associated with chronic inflammatory diseases including atherosclerosis. Monocytes and macrophages are proposed to play key roles in HCMV dissemination to host tissue, and their infection provides a biological link between the lifecycle of HCMV and disease pat...

The 9 1 integrin accelerates cell migration through binding of spermidine/spermine acetyltransferase (SSAT) to the 9 cytoplasmic domain. We now show that SSAT enhances 9-mediated migration specifically through catabolism of spermidine and/or spermine. Because spermine and spermidine are effective blockers of K ion efflux through inward-rectifier K (Kir) channels, we examined the involvement of ...

Cuddapah VA, Sontheimer H. Ion channels and tranporters in cancer. 2. Ion channels and the control of cancer cell migration. Am J Physiol Cell Physiol 301: C541–C549, 2011. First published May 4, 2011; doi:10.1152/ajpcell.00102.2011.—A hallmark of high-grade cancers is the ability of malignant cells to invade unaffected tissue and spread disease. This is particularly apparent in gliomas, the mo...

PURPOSE The effects of insulin-like growth factor (IGF)-1 on laminin (Ln)-5 and the associated integrins during in vitro HCEC migration were examined. Also investigated were the effects of IGF-1 on the migration of human corneal epithelial cells (HCECs). METHODS HCEC migration was examined by wound-healing and chemoattraction assays. For migration inhibition assays, HCECs were pretreated with...

Members of the Rho family of small GTPases, such as Rho and Rac, are required for actin cytoskeletal reorganization during the migration of carcinoma cells. Phosphodiesterases are necessary for this migration because they alleviate cAMP-dependent protein kinase (PKA)-mediated inhibition of RhoA (O'Connor, K. L., Shaw, L. M., and Mercurio, A. M. (1998) J. Cell Biol. 143, 1749-1760; O'Connor K. L...

one of the key issues of migration concerns women’s migration. this article, examines the conditions of skilled immigrant women in ehran. qualitative method is used to collect the necessary data for this tudy. the research also conducts in-depth interview with 25 immigrate women residing in tehran. the results of the research show that migration decisions depend on multiple factors including la...

abstractagriculture is considered as one of the important sectors of economic. that in the production of food and industrial crops may play an important role in economic development. in this regard human resource is very important. so that quantitative and qualitative changes in the human resources can lead to major changes in agricultural production and it influences completely agricultural pr...