BACKGROUND Keratoconus is characterized as a bilateral, progressive, non-inflammatory thinning of the cornea resulting in blurred vision due to irregular astigmatism. Keratoconus has a multifactorial etiology, with multiple genetic and environmental components contributing to the disease pathophysiology. Several genomic loci and genes have been identified that highlight the complex molecular et...

Collagen crosslinking is a relatively new treatment for structural disorders of corneal ectasia, such as keratoconus. However, there is a lack of animal models of keratoconus, which has been an obstacle for carefully analyzing the mechanisms of crosslinking and evaluating new therapies. In this study, we treated rabbit eyes with collagenase and chondroitinase enzymes to generate ex vivo corneal...

PURPOSE To compare long-term keratometric changes after penetrating keratoplasty (PK) for keratoconus and Fuchs endothelial dystrophy. METHODS We retrospectively analyzed 168 corneas after PK for keratoconus (85 eyes of 63 subjects) and Fuchs dystrophy (83 eyes of 60 subjects). Patients were examined after final suture removal at 12 months after PK to 30 years after surgery. Operations were p...

BACKGROUND Several case-control studies have been performed to examine the association of genetic variants in lysyl oxidase (LOX) with keratoconus. However, the results remained inconclusive and great heterogeneity might exist across populations. METHOD A comprehensive literature search for studies that published up to June 25, 2015 was performed. Summary odds ratios (OR) and 95% confidence i...

A case of acquired posterior keratoconus is presented. As in developmental cases the vision was moderately reduced and the condition was not progressive. Posterior keratoconus is usually developmental in origin, but trauma has been implicated in some cases.

Abstract Today, corneal refraction, height, and thickness data, which are required in the diagnosis of keratoconus, can be obtained with tomography devices. Pentacam four map display presenting this data is one most basic options keratoconus. In article, an artificial intelligence‐based method using images proposed to distinguish keratoconus from healthy eyes. Axial/sagittal curvature, back ele...

PURPOSE Brittle cornea syndrome 1 (BCS1) is a rare recessive condition characterized by extreme thinning of the cornea and sclera, caused by mutations in ZNF469. Keratoconus is a relatively common disease characterized by progressive thinning and ectasia of the cornea. The etiology of keratoconus is complex and not yet understood, but rare ZNF469 variants have recently been associated with dise...

PURPOSE Keratoconus is characterized by the thinning of corneal stroma, resulting in reduced vision. The exact etiology of keratoconus (KC) is still unknown. The involvement of oxidative stress (OS) in this disease has been reported. However, the exact mechanism of OS in keratoconus is still unknown. Thus we planned this study to screen mitochondrial complex I genes for sequence changes in kera...

PURPOSE The purpose of the study was to determine molecular changes in selected epithelial proteins in human keratoconus (KC) corneas compared to normal corneas. METHODS Two-dimensional (2-D) gel electrophoretic profiles of epithelial cell proteins from normal and keratoconus corneas were compared, and the selected protein spots that showed either up- or downregulation were identified. The de...

Keratoconus is an evolving condition. The speed and severity of the course differs from patient to patient. We report clinical observation a 36-year-old with history severe atopy who presents neglected bilateral keratoconus. examination found sign Munson Rizzuti, corneal protrusion being more marked in left eye. Biomicroscopic revealed opacity central right eye thinning. In eye, there was strom...