Gorlin-Goltz syndrome is an autosomal dominant disorder principally characterized by cutaneous basal cell carcinomas, multiple keratocystic odontogenic tumors, and skeletal anomalies. This syndrome may be diagnosed early by dentist because keratocystic odontogenic tumors are usually one of the first manifestations of the syndrome. Early diagnosis and treatment are of utmost importance in reduci...

background: cyclo-oxygenase-2 (cox-2) is an early response gene that is induced by growth factors, oncogenes and carcinogens and its expression is increased in various tumors. increased expression of cox-2 plays a signifi cant role in the development and growth of tumors by interfering in biological processes such as cell division, cellular immunity, cell adhesion, apoptosis, and angiogenesis. ...

The oral cavity may represent a reservoir of Pseudomonas aeruginosa, especially in patients with periodontitis; this makes treatment more difficult and, in the case of opportunistic infections, may worsen the conditions of debilitated patients, such as the elderly and immunossupressed. The present investigation aims at using a clinical case to discuss the possibility of a secondary infection of...

A 15-year-old girl was referred to a dentist complaining of parageusia, bad taste in the mouth, which started 9 months ago. Panoramic X-ray and non-enhanced computed tomography scan revealed multiple bilateral unilocular cysts in the mandible and maxilla, along with calcification of anterior part of the falx cerebri. She was eventually diagnosed with Gorlin-Goltz syndrome based on imaging and h...

OBJECTIVE This article presents the results of a retrospective study of the frequency and classification of odontogenic tumors recorded at four centers of diagnostic pathology in Rio de Janeiro, Brazil. STUDY DESIGN All medical records and microscopic slides of odontogenic tumor specimens for the years 1997 to 2007 were retrieved from the files of four services of diagnostic pathology in Rio ...