Background: Starch of sweet potatoes is one the ingredients that has many benefits, including in pharmaceutical field, especially as a excipient formulations. But it poor flow properties. Objective: The objective study to isolate, characterise, modify and formulate starch Purple (I. batatas L.Poir) into tablet dosage forms. Method: purple potato obtained from isolation, then modified improve it...

background: adjuvants such as ketamine, promethazine and paracetamol could bring up patients satisfaction and control harmful effects of opioids besides lessening their needed doses, as seen by fentanyl/paracetamol and fentanyl/ketamine combination before. the current study headed to compare paracetamol and ketamine in addition to fentanyl applied by infusion pumps in order to pain relief follo...

Tablets of mutual prodrugs of ibuprofen, i.e, ‘ibuprofen with paracetamol’ and ‘ibuprofen with salicylamide,’ were prepared by direct compression method. The preformulation studies such as flow property, solid state stability at elevated temperatures, solid state stability under different humidity conditions, photolytic stability and compatibility studies of prodrugs with excipients were also p...

BACKGROUND The aim of this study was to evaluate matrix tablets containing different ratios of Carbopol(®) 971P (CP) to low-viscosity sodium alginate (SA) and assess their suitability for pH-independent controlled drug release. METHODS Two processing methods (physical mixing, PM and spray-drying, SD) were applied before compaction and the release from corresponding matrices was compared. The ...

The use of partially pregelatinized starch in tablet formulations is entirely various; one them disintegrant. Present imported from another country, which relatively expensive. In contrast, many plants can be used as sources, including cassava abundant Indonesia. This study aimed to determine the effect using a disintegrant paracetamol tablets. this study, seven formulas were with different dis...

Spectrophotometric techniques were developed for the determination of single and binarymixture Promethazine hydrochloride (PMH) and Paracetamol (PCM). Normal and first derivative (D) used for single drug at λ 249.5 and 243.0 for PMH and 243.5 and 225 for PCM. The simultaneous determination of binary mixture (PMH) and (PCM) were accomplished by first derivative (D) and second derivative (D) spec...

A 2(3) factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), binder concentration (c) and relative density of tablet (d) on the disintegration time (DT) and dissolution times, t1, t50 and t90, of paracetamol tablet formulations. The factorial design was also used to study the quantitative effects of pregelatinization ...