A.N. Andreyev, S. Antalic, D. Ackermann, S. Franchoo, F. P. Heßberger, S. Hofmann, M. Huyse, I. Kojouharov, B. Kindler, P. Kuusiniemi, S. R. Lesher, B. Lommel, R. Mann, G. Münzenberg, K. Nishio, R.D. Page, J. Ressler, B. Streicher, B. Sulignano, P. Van Duppen, and D. Wiseman TRIUMF, 4004 Wesbrook Mall, Vancouver BC, Canada, V6T 2A3; Department of Nuclear Physics, Comenius University, Bratislava...

By the reaction of furan-2-carboxylic acids and furfural with diazonium salts 1a-j arylfuran-2-carboxylic 4a-e 5-arylfuran-2-carbaldehydes 5a-f were synthesized. Acids transformed into appropriated acylchlorides 6a-e used for preparation 4-(5-aryl-2-furoyl)morpholines 7a-e . 4-[(5-Aryl-2-furyl)carbonothioyl]morpholines 8a-f prepared from aldehydes by using Willgerodt-Kindler reaction. The struc...

1027. 31. Davis ID, Wiseman GA, Lee FT, Gansen DN, Hopkins W, Papenfuss AT, Liu Z, Moynihan TJ, Croghan GA, Adjei AA, Hoffman EW, Ingle JN, Old LJ, Scott AM. A phase I multiple dose, dose esca-lation study of cG250 monoclonal antibody in patients withadvanced renal cell carcinoma. Cancer Immun 2007; 7: 13. URL: http://www.cancerimmunity.org/v7p13/070713.htm 32. Bevan P, Mala C, Kindler ...

Kindler Syndrome (KS), characterized by transient skin blistering followed by abnormal pigmentation, skin atrophy, and skin cancer, is caused by mutations in the FERMT1 gene. Although a few KS patients have been reported to also develop ulcerative colitis (UC), a causal link to the FERMT1 gene mutation is unknown. The FERMT1 gene product belongs to a family of focal adhesion proteins (Kindlin-1...

Loss of Kindlin 1 (Kin1) results in the skin blistering disorder Kindler Syndrome (KS), whose symptoms also include skin atrophy and reduced keratinocyte proliferation. Kin1 binds to integrins to modulate their activation and more recently it has been shown to regulate mitotic spindles and cell survival in a Plk1-dependent manner. Here we report that short-term Kin1 deletion in mouse skin resul...

MGS is an uncommon congenital optic disc anomaly, which was first described by Kindler [1]. It is characterized by an enlarged funnel-shaped dysplastic disc with glial tissue. The retinal vessels are increased in number, appear to arise from the disc edge and run an abnormally straight course over the peripapillary retina [2,3]. Retinal detachment may occur in about one-third of cases of MGS [4...