introduction: it is believed that injury potential has a regulatory role in wound healing process and the application of exogenous electrical stimulation may serve to mimic the natural endogenous bioelectric current so that can improve the wound healing. up to now, this hypothesis has not been researched in surgically acute wounds. materials and methods: thirty nine male guinea pigs were random...

Let M be a triangulated, orientable 2-manifold of genus g without boundary, and let h be a height function over M that is linear within each triangle. We present a kinetic data structure (KDS) for maintaining the Reeb graph R of h as the heights of M’s vertices vary continuously with time. Assuming the heights of two vertices of M become equal only O(1) times, the KDS processes O((κ + g)n polyl...

Markov modeling provides an effective approach for modeling ion channel kinetics. There are several search algorithms for global fitting of macroscopic or single-channel currents across different experimental conditions. Here we present a particle swarm optimization(PSO)-based approach which, when used in combination with golden section search (GSS), can fit macroscopic voltage responses with a...

A 21-year-old male was admitted with severe right arm and hand tremors after a thalamic hemorrhage caused by a traffic accident. He was also suffering from agonizing pain in his right shoulder that manifested after the tremor. Neurologic examination revealed a disabling, severe, and irregular kinetic and postural tremor in the right arm during target-directed movements. There was also an irregu...

Cyclic GMP-AMP synthase (cGAS) is activated by ds-DNA binding to produce the secondary messenger 2',3'-cGAMP. cGAS is an important control point in the innate immune response; dysregulation of the cGAS pathway is linked to autoimmune diseases while targeted stimulation may be of benefit in immunoncology. We report here the structure of cGAS with dinucleotides and small molecule inhibitors, and ...

To maintain ATP constant in the cell, mitochondria must sense cellular ATP utilization and transduce this demand to F0-F1-ATPase. In spite of a considerable research effort over the past three decades, no combination of signal(s) and kinetic function has emerged with the power to explain ATP homeostasis in all mammalian cells. We studied this signal transduction problem in intact human muscle u...

Background It has been suggested that parkinsonian [Parkinson's disease (PD)] patients might have a "dominant" (DOM) subthalamic nucleus (STN), whose unilateral electrical stimulation [deep brain stimulation (DBS)] could lead to an improvement in PD symptoms similar to bilateral STN-DBS. Objectives Since disability in PD patients is often related to gait problems, in this study, we wanted to ...

242 words, Introduction647 words, Discussion1499 words. 17 Disclosures / Conflict of Interests 18 The authors declare that no competing interests exist. BR, JG, and KMC performed 19 experiments and data analysis, and BR and KMC wrote the paper. 20

We review the state-of-the-art in the modelling of the aggregation and collective behavior of interacting agents of similar size and body type, typically called swarming. Starting with individual-based models based on “particle”-like assumptions, we connect to hydrodynamic/macroscopic descriptions of collective motion via kinetic theory. We emphasize the role of the kinetic viewpoint in the mod...