نتایج جستجو برای: kpc gene
تعداد نتایج: 1147958 فیلتر نتایج به سال:
Klebsiella pneumoniae is a wide-spread nosocomial pathogen. A rapid and sensitive molecular method for the detection of K. pneumoniae in clinical samples is needed to guide therapeutic treatment. In this study, we first described a loop-mediated isothermal amplification (LAMP) method for the rapid detection of capsular polysaccharide synthesis regulating gene rcsA from K. pneumoniaein clinical ...
Vaborbactam (formerly RPX7009) is a new β-lactamase inhibitor based on a cyclic boronic acid pharmacophore with potent inhibitory activity against Klebsiella pneumoniaecarbapenemases (KPC). It has been developed in combination with meropenem. The objective of these studies was to identify the concentrations of both agents associated with the selection or prevention of single-step mutations lead...
مقدمه: وجود مقاومت آنتی بیوتیکی در سویه های کلبسیلاپنومونیه یکی از چالش ها و نگرانی های سلامتی انسان است. اهداف این مطالعه بررسی فراوانی مقاومت به داروهای کارباپنم در سویه های کلبسیلاپنومونیه و تعیین الگوی مقاومت اکتسابی آن ها به منظور به دست آوردن کاراترین آنتی بیوتیک ها و بررسی فنوتیپی فراوانی آنزیم کارباپنماز kpc بود. مواد و روش ها: این مطالعه مقطعی-توصیفی بر روی نمونه های بالینی شا...
Background: Carbapenemase genes have been spread among strains of Klebsiella pneumoniae that make them resistant to carbapenems. Hence, the present study aimed to study the prevalence of carbapenmase genes within K. pneumoniae isolates in Kermanshah medical centers. Methods: Sixty isolates of K. pneumoniae were collected and identified using API kit. Then, antibiotic susceptibility of isolat...
Carbapenem-resistant Klebsiella pneumoniae isolates are an important cause of nosocomial infections. This study evaluated a rapid cost-saving method based on MALDI-TOF technology, was and compared it with phenotypic, genotypic and epidemiological data for characterization of KPC-Kp strains consecutively isolated during a supposed outbreak. Twenty-five consecutive KPC Klebsiella pneumoniae isola...
KPC-producing Klebsiella pneumoniae isolates have emerged as important pathogens of nosocomial infections, and tigecycline is one of the antibiotics recommended for severe infections caused by KPC-producing K. pneumoniae. To identify the susceptibility profile of KPC-producing K. pneumoniae to tigecycline and investigate the role of efflux pumps in tigecycline resistance, a total of 215 KPC-pro...
Introduction: Pseudomonas aeruginosa is one of the most important bacteria causing nosocomial infections, especially in immunocompromised patients. Many antibiotics such as aminoglycosides, quinolones, and beta-lactams are used to treat infections caused by this bacterium. But the emergence of hospital resistance and outbreaks of resistance strains have been widely reported. The aim of this stu...
the objective of this study was to determine the phenotypic characteristics of kpc-producing pseudomonas aeruginosa and acinetobacter baumannii isolates. a case report study was performed at a tertiary burn care centre in tehran, iran. nine isolates of pseudomonas aeruginosa and acinetobacter baumannii from a hospitalized case were isolated. the identity of isolates was confirmed and the...
The present work reports the detection of the first case of nosocomial Klebsiella oxytoca producing class A carbapenemase KPC-2 in Brazil. The isolate KPN106 carried a 65-kb IncW-type plasmid that harbors the blaKPC gene and Tn4401b. Moreover, we detected the presence of a class 1 integron containing a new allele, arr-8, followed by a 5'-truncated dhfrIIIc gene. In view of the recent results, w...
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