Targeting the PD-1/PD-L1 immune checkpoint signaling is a novel promising treatment strategy in several tumor entities, and it is suggested that PD-L1/PD-1 expression is predictive for a PD-1/PD-L1 checkpoint inhibitor treatment response. We investigated the expression of PD-L1 and PD-1 by immunohistochemistry in a large and well characterized gastric cancer (GC) cohort of Caucasian patients, c...

BACKGROUND The dynamics of PD-L1 expression may limit its use as a tissue-based predictive biomarker. We sought to expand our understanding of the dynamics of PD-L1 expression and tumor-infiltrating lymphocytes (TILs) in patients with lung cancer-related brain metastases. EXPERIMENTAL DESIGN Paired primary lung cancers and brain metastases were identified and assessed for PD-L1 and CD3 expres...

We use graph-algebraic results proved in [8] and some results of the graph theory to characterize all pairs 〈L1,L2〉 of lattices for which there is a finite partial unary algebra such that its weak and strong subalgebra lattices are isomorphic to L1 and L2, respectively. Next, we describe other pairs of subalgebra lattices (weak and relative, etc.) of a finite unary algebra. Finally, necessary a...

  Objective(s):  Infection by high-risk papillomavirus is regarded as the major risk factor in the development of cervical cancer. Recombinant DNA technology allows expression of the L1 major capsid protein of HPV in different expression systems, which has intrinsic capacity to self-assemble into viral-like particles (VLP). VLPS are non-infectious, highly immunogenic and can elicit neutralizing...

Maximum A Posteriori (MAP) estimates in inverse problems are often based on quadratic formulations, corresponding to a Least Squares fitting of the data and to the use of the L2 norm on the regularization term. While the implementation of this estimation is straightforward and usually based on the Gauss Newton method, resulting estimates are sensitive to outliers, and spatial distributions of t...

There has been a considerable shift in opinion recent years concerning the use of language learners’ first (L1) teaching and learning second (L2). Recent research revealed that L1 is less problematic than once believed. That research, however, yet to consider multiple contextual factors affecting use, notably Algerian context. The current study explored beliefs held by teachers English as Forei...

Over one-third of human genome sequence is a product of non-LTR retrotransposition. The retrotransposon that currently drives this process in humans is the highly abundant LINE-1 (L1) element. Despite the ubiquitous nature of L1's in mammals, we still lack a complete mechanistic understanding of the L1 replication cycle and how it is regulated. To generate a genetically amenable model for non-L...

The adenovirus major late transcription unit (MLTU) encodes five families of mRNAs, L1 to L5, each distinguished by a unique poly(A) site. Use of the promoter-proximal L1 poly(A) site predominates during early infection, whereas poly(A) site choice shifts to the promoter-distal sites during late infection. A mini-MLTU containing only the L1 and L3 poly(A) sites has been shown to reproduce this ...