The Naval Research Laboratory’s spectral element atmospheric model (NSEAM) for scalable computer architectures is presented. This new dynamical core is based on a high-order spectral element (SE) method in space and uses semi-implicit methods in time based on either the traditional second-order leapfrog (LF2) or second-order backward difference formulas (BDF2). The novelties of NSEAM are: it is...

Increasing concentrations of ethidium bromide cause progressive inactivation of ribosomes, apparently by binding to double-stranded regions of the rRNA. At low drug concentrations (10(-4)M) the partial inhibition detected is due to specific release of proteins L7 and L12; activity can be restored by addition of an excess of these two proteins. At higher concentrations the inactivation is not re...

Most mitochondrial proteins are synthesized in the cytosol as precursor proteins containing an N-terminal targeting peptide and are imported into mitochondria through the import machineries, the translocase of the outer mitochondrial membrane (TOM) and the translocase of the inner mitochondrial membrane (TIM). The N-terminal targeting peptide of precursor proteins destined for the mitochondrial...

The nasopharynx is frequently colonized by both commensal and pathogenic bacteria including Streptococcus pneumoniae (pneumococcus). Pneumococcus is an important pathogen responsible for bacterial meningitis and community acquired pneumonia but is also commonly an asymptomatic colonizer of the nasopharynx. Understanding interactions between microbes may provide insights into pathogenesis. Here,...

Article history: Received 3 January 2013 Received in revised form 7 May 2014 Accepted 7 May 2014 Available online 21 May 2014 This study investigates current status of balanced scorecard (BSC) application and its impact on hospital performance in China. A nationwide survey indicates that a large portion of Chinese public hospitals have adopted BSC in hospital administration at present. By apply...

Two different transcription termination control mechanisms, the T box and S box systems, are used to regulate transcription of many bacterial aminoacyl-tRNA synthetase, amino acid biosynthesis, and amino acid transport genes. Both of these regulatory mechanisms involve an untranslated mRNA leader region capable of adopting alternate structural conformations that result in transcription terminat...

We have investigated the protein-protein cross-links formed within the 50 S subunit of the Escherichia coli ribosome using 2-iminothiolane as the cross-linking reagent. The members of the cross-links have been identified by immunoblotting from one-dimensional and two-dimensional diagonal sodium dodecyl sulfate-polyacrylamide gels using antisera specific for the individual ribosomal proteins. Th...

D’Angio, Carl T., Michael B. LoMonaco, Carl J. Johnston, Christina K. Reed, and Jacob N. Finkelstein. Differential roles for NFB in endotoxin and oxygen induction of interleukin-8 in the macrophage. Am J Physiol Lung Cell Mol Physiol 286: L30–L36, 2004. First published August 8, 2003; 10.1152/ajplung.00360.2002.—The alveolar macrophage is an important source of interleukin (IL)-8 during pulmona...