INTRODUCTION This study was conducted to assess the prevalence of metallo-beta-lactamases (MBLs) in general and blaNDM-1 in particular. It also aimed at evaluating clinical characteristics and outcome in patients infected with MBLs. MATERIALS AND METHODS A total of 116 carbapenem-resistant Gram-negative bacilli (CRGNB) were evaluated in the study. These CRGNB were tested for MBL production bo...

BACKGROUND The increasing rates of antimicrobial resistance observed in the nosocomial pathogen Klebsiella pneumoniae are of major public health concern worldwide. OBJECTIVES To describe the antibiotic susceptibility profiles of K. pneumoniae isolates from bacteraemic patients submitted by sentinel laboratories in five regions of South Africa from mid-2010 to mid-2012. Molecular methods were ...

OBJECTIVES Despite the fact that the NDM-1 carbapenemase has successfully disseminated worldwide, outbreaks remain uncommon in the European region. We describe the characteristics of the first outbreaks caused by NDM-1-producing Klebsiella pneumoniae clonal isolates in Greece. METHODS Between January 2010 and June 2013, 132 non-repetitive carbapenem-resistant Enterobacteriaceae isolates, whic...

Abstract Background Antibiotic resistant infections are a risk for increased patient mortality due to long time-to-results current diagnostic methods. Results from ∼1,500 trial demonstrated bacterial blood culture required 51 hours on average positive result. Current antibiotic susceptibility testing (AST) requires two additional days phenotypic results. Studies show delays in effective treatme...

BACKGROUND Carbapenem-resistant Acinetobacter baumannii has emerged as an important cause of infection in burn patients. This study aimed to characterize the antimicrobial susceptibility pattern, determine the prevalence of oxacillinase and metallo-beta-lactamase (MBL) genes, and type the A. baumannii isolates obtained from burn patients. METHODS During a 1-year period, a total of 40 nondupli...

An NDM-1 carbapenemase-producing Pseudomonas aeruginosa isolate was recovered from a patient hospitalized in France after a previous hospitalization in Serbia. Genetic studies revealed that the blaNDM-1 gene was surrounded by insertion sequence ISAba125 and a truncated bleomycin resistance gene. This blaNDM-1 region was a part of the variable region of a new complex class 1 integron bearing IS ...

Carbapenem-resistant Acinetobacter baumannii has been considered one of the major threats to patients worldwide. To evaluate carbapenemase in several clinical isolates using phenotypic and genotypic approaches. A total 49 A. were tested against imipenem meropenem discs on Muller Hinton agar, then screened phenotypically through modified Hodge test (MHT), combined disc (CDT) carbapenem inactivat...

There is an error in the penultimate sentence of the “Detection of blaNDM-1 positive isolates” subsection of the Results. The correct sentence is: These isolates were collected from 8 individual patients, consisting of 5 male (62.5%) and 3 female (37.5%) with a mean age of 29.7 years, including 2 infants (ECL-2, ECL-36). There is an error in Table 2, “Characteristics of blaNDM-1-positive E. clo...

The genus Raoultella is composed of Gram-negative, aerobic, oxidase-negative, catalase-positive, nonmotile, capsulated rods belonging to the Enterobacteriaceae family (1). Raoultella ornithinolytica is found in aquatic and hospital environments (2). Occurrence of Raoultella in human infections is rare, but it has been reported to cause bloodstream and soft tissue infections (2–5). A 67-year-old...

We determined the in vitro susceptibility of four aminoglycosides, which are not of the 4,6-disubstituted deoxystreptamine (DOS) subclass against a collection of carbapenem-resistant Enterobacteriaceae (CRE). CRE clinical strains (n = 134) were collected from multiple hospitals in China and carried blaNDM (blaNDM-1, blaNDM-5 or blaNDM-7; n = 66), blaKPC-2 (n = 62) or blaIMP-4 (n = 7; including ...