The treatment of acute ischemic stroke (AIS) in the setting of intracranial large artery occlusion (LAO) with intravenous tissue plasminogen activator (IV-tPA) is associated with low rates of recanalization and high rates of neurological morbidity and functional dependence. Endovascular intervention, particularly mechanical thrombectomy, is a promising therapeutic adjunct to IV-tPA for the trea...

Plant lateral aerial organ (LAO) growth is determined by the number and size of cells comprising the organ. Genetic alteration of one parameter is often accompanied by changes in the other, such that the overall effect on final LAO size is minimized, suggested to be caused by an active organ level 'compensation mechanism'. For example, the aintegumenta (ant) mutant exhibits reduced cell number ...

Snake venoms are rich in enzymes such as phospholipase A2, proteolytic enzymes, hyaluronidases and phosphodiesterases, which are well characterized. However, L-amino acid oxidase (LAO EC.1.4.3.2) from snake venoms has not been extensively studied. A novel L-amino acid oxidase from Bungarus caeruleus venom was purified to homogeneity using a combination of ion-exchange by DEAE-cellulose chromato...

Learn-and-Optimize (LaO) is a generic surrogate based method for parameter tuning combining learning and optimization. In this paper LaO is used to tune Divide-and-Evolve (DaE), an Evolutionary Algorithm for AI Planning. The LaO framework makes it possible to learn the relation between some features describing a given instance and the optimal parameters for this instance, thus it enables to ext...

Learn-and-Optimize (LaO) is a generic surrogate based method for parameter tuning combining learning and optimization. In this paper LaO is used to tune Divide-and-Evolve (DaE), an Evolutionary Algorithm for AI Planning. The LaO framework makes it possible to learn the relation between some features describing a given instance and the optimal parameters for this instance, thus it enables to ext...

Although both LaAlO3 (LAO) and SrTiO3 (STO) are insulators, at the interface of LAO/STO [001] stacking structures, formation of two-dimensional electronic gas with high mobility was reported [1]. Associated with this, a problem concerning divergence of electrostatic potential was also pointed out [2]. We performed first-principles calculations on LAO/STO [001] stacking thin films and investigat...

Healthcare-associated infections (HAIs) are causes of mortality and morbidity worldwide. The prevalence of bacterial resistance to common antibiotics has increased in recent years, highlighting the need to develop novel alternatives for controlling these pathogens. Pitviper venoms are composed of a multifaceted mixture of peptides, proteins and inorganic components. L-amino oxidase (LAO) is a m...

Learn-and-Optimize (LaO) is a generic surrogate based method for parameter tuning combining learning and optimization. In this paper LaO is used to tune Divide-and-Evolve (DaE), an Evolutionary Algorithm for AI Planning. The LaO framework makes it possible to learn the relation between some features describing a given instance and the optimal parameters for this instance, thus it enables to ext...

Learn-and-Optimize (LaO) is a generic surrogate based method for parameter tuning combining learning and optimization. In this paper LaO is used to tune Divide-and-Evolve (DaE), an Evolutionary Algorithm for AI Planning. The LaO framework makes it possible to learn the relation between some features describing a given instance and the optimal parameters for this instance, thus it enables to ext...