CONTEXT Congenital hyperinsulinism (HI) is a common cause of hypoglycemia in infancy. The medical treatment of diazoxide-unresponsive HI is based on a somatostatin analogue. OBJECTIVE This study aims at replacing three daily s.c. octreotide (Sandostatin, Novartis) injections by a single and monthly i.m. injection of long-acting release (LAR) octreotide (Sandostatin LP, Novartis) in HI patient...

The location-aided routing scheme 1 (LAR-1) and probabilistic algorithms are combined together into a new algorithm for route discovery in mobile ad hoc networks (MANETs) called LAR-1P. Simulation results demonstrated that the LAR-1P algorithm reduces the number of retransmissions as compared to LAR-1 without sacrificing network reachability. Furthermore, on a sub-network (zone) scale, the algo...

The prediction of leaf appearance rate (LAR) is an important part of many crop simulation models. Most wheat simulations models assume that LAR is affected by temperature and photoperiod. This assumption ignores the fact that seed reserves contribute to a greater LAR of the first two leaves and that the LAR of subsequent leaves decreases as a result of an increase in the distance that each leaf...

The human beta-globin locus activation region (LAR) comprises four erythroid-specific DNase I hypersensitive sites (I-IV) thought to be largely responsible for activating the beta-globin domain and facilitating high-level erythroid-specific globin gene expression. We identified the goat beta-globin LAR, determined 10.2 kilobases of its sequence, and demonstrated its function in transgenic mice....

Routing in Mobile Ad-Hoc Network (MANET) is a crucial task due to highly dynamic network environment. In latest years, several routing protocols have been implemented. In recent developments, position-based routing protocols exhibit better scalability performance and robustness against frequent topological changes such as, Location-Aided Routing (LAR) protocol. In this paper, developments of pe...

The stem cell niche provides a supportive microenvironment to maintain adult stem cells in their undifferentiated state. Adhesion between adult stem cells and niche cells or the local basement membrane ensures retention of stem cells in the niche environment. Drosophila male germline stem cells (GSCs) attach to somatic hub cells, a component of their niche, through E-cadherin-mediated adherens ...

Receptor protein tyrosine phosphatases (RPTPs) control many aspects of nervous system development. At the Drosophila neuromuscular junction (NMJ), regulation of synapse growth and maturation by the RPTP LAR depends on catalytic phosphatase activity and on the extracellular ligands Syndecan and Dally-like. We show here that the function of LAR in controlling R7 photoreceptor axon targeting in th...

Vehicular ad-hoc network (VANET) is an integral component of intelligent transportation systems. Due to continuous movement of vehicles, network formation and deformation is very frequent. Furthermore, for safety applications, we wish to create the communication without any delay or collision. Therefore, communication among the vehicles is even more challenging. D-LAR (Directional– Location Aid...