A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their anti platelet aggregation activities were assessed against ADP and arachidonic acid- induced platelet aggregation in human plasma using light transmission aggregometry. None of the compounds showed satisfactory activity against the aggregation induced by ADP. However, satisfac...

aggregation operators (aos) have been studied by many schol- ars. as many aos are proposed, there is still lacking approach to classify the categories of ao, and to select the appropriate ao within the ao candidates. in this research, each ao can be regarded as a cognitive style or individual dierence. a cognitive style and aggregation operator (csao) model is pro- posed to analyze the mapping ...

In the last few years, hydrostatic pressure has been extensively used in the study of both protein folding and misfolding/aggregation. Compared to other chemical or physical denaturing agents, a unique feature of pressure is its ability to induce subtle changes in protein conformation, which allow the stabilization of partially folded intermediate states that are usually not significantly popul...

Fuzzy Description Logics (Fuzzy DLs) are logics that allow to deal with structured knowledge affected by fuzziness. Fuzzy DLs are at the heart of Fuzzy OWL 2, a fuzzy version of the standard ontology language OWL 2. Although a relatively important amount of work has been carried out in the last years, fuzzy DLs are open to be extended with several features worked out in other fields. In particu...

The relationship of the shape and structure of uniform colloidal particles to different mechanisms of formation by precipitation in homogeneous solutions is reviewed. Specifically, conditions leading to (a) amorphous spheres, (b) nonspherical crystals of different shapes, and (c) polycrystalline particles of different morphologies including spheres are distinguished. The last case is observed w...

A computationally efficient algorithm is presented for exact simulation of the stochastic time evolution of spatially homogeneous aggregation-fragmentation processes featuring multiple components or conservation laws. The algorithm can predict the average size and composition distributions of aggregating particles as well as their fluctuations, regardless of the functional form (e.g., compositi...

In order to decrease computational costs and memory requirements of relatively expensive classical algebraic multigrid (AMG) methods, we investigate its combination with aggressive coarsening schemes based on the plain (non-smoothed) aggregation on a fixed number of fine levels. Equivalently, we replace the direct solver on the coarsest level of the aggregation method with an inexact classical ...

Understanding the role of biomolecular dynamics in cellular processes leading to human diseases and the ability to rationally manipulate these processes is of fundamental importance in scientific research. The last decade has witnessed significant progress in probing biophysical behavior of proteins. However, we are still limited in understanding how changes in protein dynamics and inter-protei...

The study of protein aggregation saw a renaissance in the last decade, when it was discovered that aggregation is the cause of several human diseases, making this field of research one of the most exciting frontiers in science today. Building on knowledge about protein folding energy landscapes, determined using an array of biophysical methods, theory and simulation, new light is now being shed...

BACKGROUND In our previous study we found that the expression of stlA showed peaks both in the early and last stages of development and that a product of SteelyA, 4-methyl-5-pentylbenzene-1,3-diol (MPBD), controlled Dictyostelium spore maturation during the latter. In this study we focused on the role of SteelyA in early stage development. PRINCIPAL FINDINGS Our stlA null mutant showed aggreg...