Summary: SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA associated with cancer pathogenesis. It contributes to a variety of cellular functions and recent evidence propounds its association with autophagy process. It has been showed that SOX2OT can regulate the expression of different autophagy associated factors in human cells with different mechanisms, however more remains to ...

Herpes simplex virus (HSV) latent infection of ganglion neurons follows axoplasmic transport of HSV, probably in the form of nucleocapsid from peripheral sites of infection (e.g. footpad). This raises the possibility that latency is dependent on this particular means of presenting HSV to ganglion neurons. To investigate this, we directly infected ganglia of mice with HSV and evaluated latency. ...

The herpes simplex virus latency-associated transcript (LAT) gene is the only viral gene that shows substantial transcriptional activity during neuronal latency. The LAT RNA produced is antisense to the mRNA of the immediate early gene ICP0, partially overlaps the ICP0 mRNA, and is suspected of playing some role in latency. Sequence analysis of the region 5' to the reported transcription start ...

Latency is one of the main challenges in the task of simultaneous spoken language translation. While significant improvements in recent years have led to high quality automatic translations, their usefulness in real-time settings is still severely limited due to the large delay between the input speech and the delivered translation. In this paper, we present a novel scheme which reduces the lat...

During herpes simplex virus type 1 (HSV-1) lifelong latency in human peripheral sensory ganglia (PSG), only the viral latency-associated transcript (LAT) gene is expressed. This raises the possibility that this gene is involved in establishment of latency of the virus, its maintenance, or reactivation. Here we present data that indicate yet another independent function of the LAT gene: interfer...

Human cytomegalovirus (CMV) establishes latent infections in hematopoietic cells such as granulocyte-macrophage progenitors (GM-Ps). During latency the virus is sequestered in a nonreplicating state, although limited transcriptional activity has been previously reported. In this study we sought to further examine viral gene expression during the latent phase of infection. Using an experimental ...