Alginate (Alg) is increasingly studied as a constitutive material of scaffolds for tissue engineering because its easy gelation and biocompatibility, the incorporation drugs into formulation allows functionality to be extended. However, Alg presents low cell adhesion proliferation capacity, may further reduce biocompatibility. Layered double hydroxides (LDH) are promising fillers Alg-based biom...

Layered double hydroxide (LDH) nanoparticles are emerging as one of the promising nanomaterials for biomedical applications, but their systemic toxicity in vivo has received little attention. In the present study, the effects of inorganic nanoparticle aggregation on their systemic toxicity were examined. Remarkably, aggregation was observed after the mixing of naked LDH nanoparticles with salin...