BACKGROUND Lead is one of the most toxic metals, producing severe organ damage in animals and humans. Oxidative stress is reported to play an important role in lead acetate-induced liver injury. AIM This study was carried out to investigate the role of ethanol extract of Eucheuma cottonii in protecting against lead acetate-induced hepatotoxicity in male mice. MATERIALS AND METHODS The sampl...

BACKGROUND Extended exposure to low levels of lead causes high blood pressure in human and laboratory animals. The mechanism is not completely recognized, but it is relatively implicated with generation of free radicals, oxidant agents such as ROS, and decrease of available nitric oxide (NO). In this study, we have demonstrated the effect of ascorbic acid as an antioxidant on nitric oxide metab...

Lead (Pb2+) is a well known neurotoxin that was frequently found in the environment and chronic exposure to lead has been matter of public health. In the present study the effect of lead on spatial memory in developmentally exposed rats and their dams in Morris water maze task were investigated. Female rats were divided into three groups and two groups exposed to 250 and 750 part per million (p...

Objectives In this study, we investigated the protective effects of piperine on lead acetate-induced renal damage in rat kidney tissue. Materials and Methods Forty male rats were divided into 5 groups: negative control (rats were given aquadest daily), positive control (rats were given lead acetate 30 mg/kg BW orally once a day for 60 days), and the treatment group (rats were given piperine 5...

The present study was conducted to investigate the protective role of Omega-3 polyunsaturated fatty acids against lead acetate-induced toxicity in liver and kidney of female rats. Animals were divided into four equal groups; group 1 served as control while groups 2 and 3 were treated orally with Omega-3 fatty acids at doses of 125 and 260 mg/kg body weight, respectively, for 10 days. These grou...

background: lead is an industrial heavy metal that can decrease sperm motility. objective: the aim was to investigate the protective effects of calcium against lead on motility of spermatozoa. materials and methods: in total 40 adult male swiss white mice were randomly divided into 5 groups (control, lead of 1st wk, lead of 2nd wk, lead/calcium of 1st wk and lead/calcium of 2nd wk). the lead gr...

The developing immune system is particularly sensitive to environmental and hormonal influences. Genders can differ in this sensitivity as well. Because the heavy metal, lead, can suppress Th-1 associated function among perinatal thymocytes and cause a systemic loss of postnatal Th-1 function, we investigated the ability of in ovo administered lead and testosterone to alter thymocyte maturation...