The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for the existence of multiple physiological functions of this hormone in rodents. In contrast, information regarding the roles of this hormone in humans is limited. Three morbidly obese children, who were congenitally deficient in lepti...

Leptin is a hormone which functions in the regulation of energy homeostasis via suppression appetite. In zebrafish, there are two paralogous genes encoding leptin, called lepa and lepb . gene expression study, we found that gene, not , was significantly downregulated under state insulin-resistance zebrafish larvae, suggesting plays role glucose homeostasis. current characterised -deficient ( −/...

It is known that leptin, an adipocyte-derived hormone, exerts a stimulatory effect on growth hormone (GH) secretion in various animal species. However, no previous study examined in vivo whether leptin affects the secretion of GH-releasing factor (GRF), somatostatin (SRIH), and some other closely relevant neurohormones in the hypothalamus. Therefore, in this study we investigated the effects of...

Leptin is a pleiotropic hormone-cytokine known to regulate energy homeostasis and immune function. Neutrophils from leptin-deficient mice exhibited impaired phagocytosis of Klebsiella pneumoniae opsonized with serum containing complement and reduced CD11b expression that could be restored with exogenous leptin. These results suggest that leptin is required for normal neutrophil complement-media...

The discovery of the adipose-derived hormone leptin has generated enormous interest in the interaction between peripheral signals and brain targets involved in the regulation of feeding and energy balance. Plasma leptin levels correlate with fat stores and respond to changes in energy balance. It was initially proposed that leptin serves a primary role as an anti-obesity hormone, but this role ...

Obesity is a chronic disease that represents one of the most serious global health burdens associated to an excess of body fat resulting from an imbalance between energy intake and expenditure, which is regulated by environmental and genetic interactions. The adipose-derived hormone leptin acts via a specific receptor in the brain to regulate energy balance and body weight, although this protei...

The study aimed to investigate the effect of in ovo (IO) leptin injection on yolk sac concentration, embryo development, blood lipid metabolism, and biochemical parameters broiler chicks during early post-hatching period. Hatching eggs were weighed placed an incubator with 100 eggs/4 replications/group. groups were: non-injected group (C); 3 injected μl phosphate buffer solution (PBS); 0.5 (L0....

OBJECTIVE Leptin is an adipocyte-derived hormone, which is the product of the obese gene and it is thought to play important roles in pubertal development and maintenance of reproductive function in the female. In a study using adult male or female rats, it was found that leptin stimulated the secretion of gonadotropin directly from the pituitary in a dose-related manner. However, there is no s...

Background & Aims: puberty is a process in which physical and physiological changes lead to changes in the child's body as an adult with reproductive capacity. The purpose of the present study was to investigate the effect of 12 weeks of moderate intensity aerobic training on serum leptin, growth hormone / Insulin-Like Growth Factor-1, in Mature and immature Inactive Girl Students. Materials &...