Neuroblastoma is a tumor of early childhood that usually originates in the sympathetic ganglia or adrenal medulla [1, 2] . Except for the rare primary cerebral neuroblastoma, involvement of brain parenchyma and leptomeninges is unusual and tends to occur in cases of widely disseminated disease [3] . To our knowledge, we report the first CT demonstration of diffuse intracranial leptomeningeal me...

Abstract There is critical need to study leptomeningeal metastasis (LM), a fatal complication of cancer accompanied by severe neurological deficits. LM occurs when cells enter the leptomeninges, float in cerebrospinal fluid (CSF), and adhere surface brain spinal cord. Understanding molecular basis requires reliable models disease that can recapitulate complex microenvironment supports cell grow...

leptomeningeal carcinomatosis (lmc) from gastrointestinal cancer would be rare. a 56-years old man with complaint of dyspepsia and histopathologic examination of the biopsy specimens has shown: adenocarcinoma. at the end of adjuvant chemo radiation therapy, the patient has affected by headache and mild confusion. in cerebrospinal fluid (csf) cytology, a plenty of malignant cells have seen and u...