analyzed data, while nurses took photographs of the nails, assisted in collection of specimens, and stored them. In total, 113 images were prepared which included 58 (51.3%) nails with tinea unguium. Diseases other than tinea unguium included onychogryphosis, pachyonychia, onycholysis, leukonychia and subungual hematoma. The dermatologists judged whether the cases in the images were tinea ungui...

A 48-year old woman affected by acute myeloid leukemia received a sequential combination of idarubicin and cytosine arabinoside as induction and consolidation therapy. After each course, transverse white bands appeared on all ten fingernails, and migrated distally as a result of nail plate growth. The temporal relationship between the white lines and drug administration is clearly shown in the ...

Onycholysis, or the separation of the nail from its bed, is a non–lifethreatening toxicity, but one that may impair function and be visibly unpleasant. Anthracyclines and taxanes, alone or in combination, are the cytotoxic drugs most frequently associated with onycholysis (1,2). During the last year, we have treated 36 patients with metastatic colorectal cancer with an irinotecan–capecitabine c...

The pitch of a sound is perhaps one of its most salient properties. It is the pitch of sounds that allows us to distinguish and recognize melodies, and the salience of pitch and melody appears to be exploited by a strikingly wide variety of vertebrate life-forms, from song birds to “singing” hump-back whales all the way to human composers of advertising jingles. But while perceptually pitch has...

1 The binaural masking level difference: cortical correlates persist despite severe brain stem atrophy 1 in progressive supranuclear palsy. 2 3 Laura E. Hughes, James B. Rowe, Boyd C.P. Ghosh, Robert P. Carlyon, Christopher J. Plack, 4 Hedwig E. Gockel 5 6 1. University of Cambridge Department of Clinical Neurosciences, CB2 2QQ, UK 7 2. Medical Research Council Cognition and Brain Sciences Unit...

The decision process in a forward-masked intensity discrimination task was studied by introducing within-trial variability in masker level. In a 2IFC paradigm, the level of the masker presented in interval 1 and interval 2, respectively, was sampled independently from a normal distribution in each trial. Mean and standard deviation of the distribution were varied. Standard level was constant; t...

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Listeria monocytogenes is considered as a potential live bacterial vector, particularly for the induction of CD8 T cells. The CD4 T-cell immune response triggered after enteral immunization of mice has not yet been thoroughly characterized. The dynamics of gamma interferon (IFN-gamma)- and interleukin-4 (IL-4)-secreting CD4 T cells were analyzed after priming through intragastric delivery of an...