BACKGROUND Helicobacter pylori cell surface is composed of lipopolysaccharides (LPSs) yielding structures homologous to mammalian Lewis O-chains blood group antigens. These structures are key mediators in the definition of host-microbial interactions and known to change their expression pattern in response to environmental pressure. AIMS The present work is focused on the identification of ne...

The metastatic potential of some tumor cells is associated with the expression of the neolactoseries antigens sialyl-Lewis x (sLex) and sialyl-Lewis a (sLea) as they are ligands for selectins. We have recently shown that peptide mimetics of these antigens can potentiate IgG2a antibodies, which are associated with a Th1-type cellular response. As L-selectin is preferentially expressed on CD4+ Th...

a simple highly versatile and efficient sonochemical synthesis of 1,2,4,5-tetrasubstituted and 2,4,5-trisubstituted imidazoles is achieved by condensation of 1,2-dicarbonyl compound, aldehyde, ammonium acetate and primary amine using antimony trichloride immobilized on silica gel (sio2-osbcl2) as a catalyst in ethanol at moderate temperature. operational simplicity, practicability and applicabi...

modern hydrometallurgical techniques have been adopted to produce high-purity gold. many extractants were used for the extraction of gold from various synthetic solutions from which dibutyl carbitol (dbc) had a unique superiority. kinetics of process was studied in this paper and the influence of several parameters such as stirring speed, agitation time, impeller type, interfacial area, [aucl4]...

Background: Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases.  The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in North Indian subjects. Methods: The variants were investig...

BACKGROUND Several monoclonal antibodies (mAbs) recognising Lewis(y), such as BR96, have reached the clinic but have failed to show good anti-tumour responses with an acceptable level of toxicity. No Lewis(b) mAbs have been trialled in patients. In this study we compare the specificity of three mAbs; BR96 (Lewis(y)), 2-25 LE (Lewis(b)) and 692/29 that recognises a unique facet of both Lewis(y) ...

Considering the high incidence and mortality rate of esophageal cancer in some areas of the country, and its diagnosis at a time of advanced growth, this study was carried out to determine the predisposing factors and the most effective and applicable surgical procedure. In this descriptive study, 158 patients (95 males and 63 females) with esophageal cancer were studied. They referred to Shoh...