نتایج جستجو برای: lifelines

تعداد نتایج: 363  

Journal: :American journal of human genetics 2015
Sonia Shah Marc J Bonder Riccardo E Marioni Zhihong Zhu Allan F McRae Alexandra Zhernakova Sarah E Harris Dave Liewald Anjali K Henders Michael M Mendelson Chunyu Liu Roby Joehanes Liming Liang Daniel Levy Nicholas G Martin John M Starr Cisca Wijmenga Naomi R Wray Jian Yang Grant W Montgomery Lude Franke Ian J Deary Peter M Visscher

We tested whether DNA-methylation profiles account for inter-individual variation in body mass index (BMI) and height and whether they predict these phenotypes over and above genetic factors. Genetic predictors were derived from published summary results from the largest genome-wide association studies on BMI (n ∼ 350,000) and height (n ∼ 250,000) to date. We derived methylation predictors by e...

2013
Kim de Jong H Marike Boezen Nick HT ten Hacken Dirkje S Postma Judith M Vonk

BACKGROUND Lung growth in utero and lung function loss during adulthood can be affected by exposure to environmental tobacco smoke (ETS). The underlying mechanisms have not been fully elucidated. Both ETS exposure and single nucleotide polymorphisms (SNPs) in Glutathione S-Transferase (GST) Omega genes have been associated with the level of lung function. This study aimed to assess if GSTO SNPs...

Journal: :Thorax 2021

Background Few large studies have assessed the relationship of long-term ambient air pollution exposure with prevalence and incidence symptoms chronic bronchitis cough. Methods We leveraged Lifelines cohort data on 132 595 (baseline) 65 009 (second assessment) participants linked to estimates. Logistic regression models adjusted for sex, age, educational attainment, body mass index, smoking sta...

Kiarash Nasserasadi Mehran Seyed Razzaghi,

Damage to essential facilities (e.g. lifelines and industrial facilities) due to extreme loads may cause remarkable indirect impact as well as direct physical loss. Hence understanding seismic performance of essential facilities is very important in high seismic risk regions. On October 23, 2011 an earthquake of magnitude Mw7.2 occurred in Van province in eastern Turkey. Several damages occurre...

Journal: :Hydrological Processes 2022

Abstract Increasing publication numbers make it difficult to keep up with knowledge evolution in a science like hydrology. Here we give recommendations authors and journals for writing future‐proof articles that contribute accumulation synthesis.

2016
Marloes Oldenkamp Rafael P. M. Wittek Mariët Hagedoorn Ronald P. Stolk Nynke Smidt

BACKGROUND Informal caregiving is becoming more relevant with current trends such as population ageing. However, little is known about nonconsent and nonresponse bias in caregiving research. We investigated nonconsent and nonresponse bias in a sample of informal caregivers who participated in the LifeLines Cohort Study, and were invited for participation in an additional caregiving study. MET...

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