G protein-coupled receptors (GPCRs) are essential cell membrane signaling molecules and represent the most important class of drug targets. Some pathways downstream a GPCR may be responsible for adverse effects, while others mediate therapeutic efficacy. Biased ligands preferentially activate only subset all pathways. They hold great potential to become next-generation drugs with less side effe...

few novel cobalt(ii) and copper(ii) complexes [m(fmp)3]cl2, [m(fmp)(bpy)2]cl2,[m(fmp)(phen)2]cl2 and [m(fmp)(phen)(bpy)]cl2 (fmp = 3-furan-2-ylmethylene-pentane-2,4-dione, phen = 1,10-phenanthroline, bpy = 2,2'-bipyridine) have been synthesized andcharacterized by elemental analyses, molar conductance, magnetic susceptibility measurements,ir, electronic, epr, mass spectra and cyclic voltam...

The force required to rupture the streptavidin-biotin complex was calculated here by computer simulations. The computed force agrees well with that obtained by recent single molecule atomic force microscope experiments. These simulations suggest a detailed multiple-pathway rupture mechanism involving five major unbinding steps. Binding forces and specificity are attributed to a hydrogen bond ne...

In this research, the generation process of engineered microsphere agarose adsorbent has been explained that has surfaces with different active sites to adsorb protein nanoparticles into the fluidized-bed system. Also, excellent selectivity of protein nanoparticles, high adsorption capacity, and fast equilibrium rate through the eco-friendly polymeric adsorbents were vital aims in here. Hence, ...

The olfactory system of mammals allows the detection and discrimination thousands odors from environment. In mammals, odorant-binding proteins (OBPs) are considered responsible to carry odorant molecules across aqueous nasal mucus receptors (ORs). three-dimensional structure these presents eight antiparallel ?-sheets a short ?-helical segment close C terminus, typical lipocalins family. great a...

In this chapter, we explore means for predicting protein residues that interact with small molecules. We will motivate the problem by describing potential uses for such information and proceed to discuss methods advanced for prediction. We describe our sequence-based approach and contrast it with another current methodwhich relies on predicted protein structure to help identify ligand-binding r...

The “integrin” terminology was applied in a 1987 review article (1) to describe a family of structurally, immunochemically, and functionally related cell-surface heterodimeric receptors, which integrated the extracellular matrix with the intracellular cytoskeleton to mediate cell migration and adhesion. The three original b subunits (b1, b2, and b3) identified have now expanded to eight, and th...

Understanding DNA–ligand binding interactions requires ligand screening, crystallization, and structure determination. In order to obtain insights into the amyloid peptide precursor (APP) gene–Thioflavin T (ThT) interaction, single crystals of two DNA sequences 5′-GCCCACCACGGC-3′ (PDB 8ASK) d(CCGGGGTACCCCGG)2 8ASH) were grown in presence ThT or its analogue 2-((4-(dimethylamino)benzylidene)amin...

Few novel cobalt(II) and copper(II) complexes [M(fmp)3]Cl2, [M(fmp)(bpy)2]Cl2,[M(fmp)(phen)2]Cl2 and [M(fmp)(phen)(bpy)]Cl2 (fmp = 3-furan-2-ylmethylene-pentane-2,4-dione, phen = 1,10-phenanthroline, bpy = 2,2'-bipyridine) have been synthesized andcharacterized by elemental analyses, molar conductance, magnetic susceptibility measurements,IR, electronic, EPR, mass spectra and cyclic voltammetri...