conclusions saturated fatty acids (sfas) served as a potential ligand for tlr4 and activated tlr4 signaling pathway, which might be involved in the pathogenesis. thus, sfas can accelerate the mechanism of inhibiting hbv replication in chb with nafld. objectives this study aimed to investigate whether the tlr4-mediated innate immunity stimulates the pathogenesis of chb in patients with nafld and...

introduction: brain-derived neurotrophic factor (bdnf) and its receptor, trkb, in the hippocampus are targets for adverse effects of stress paradigms in addition, bdnf and its receptor play key role in the pathology of brain diseases like depression. in the present study, we evaluated the possible role of hippocampal bdnf in depression during pregnancy, methods: to achieve the purpose, repeated...

To explore the expression and clinical significance of toll-like receptor 1 3 in renal tissues children with primary nephrotic syndrome. A total 120 syndrome kidney who underwent biopsy were selected as observation group, which can be divided into minimal change disease type (40 cases), membranous nephropathy (20 mesangial proliferative glomerulonephritis (30 cases) focal segmental glomeruloscl...

Diabetes mellitus can cause a decrease in tear secretion and film composition, resulting series of pathological changes such as the stability film, increased risk inflammation, peripheral neuropathy impairment meibomian glands, leading to dry eye. The imbalance inflammatory mediators diabetic patients injury ocular surface are main factors that aggravate Nod-like receptor protein 3 inflammasome...