A series of isopropyl fatty esters having different chain length (C(13)-C(23)) were synthesized and formulated in lipid nanoparticles based on Precirol ATO to evaluate their effect on the physicochemical properties of these latter. Moreover, drug loading and skin permeation of Econazole nitrate, chosen as a lipophilic model drug, were evaluated as well. The obtained nanosystems, prepared by hig...

Oral cancer (oral cavity and oropharynx) is a common and aggressive cancer that invades local tissue, can cause metastasis, and has a high mortality rate. Conventional treatment strategies, such as surgery and chemoradiotherapy, have improved over the past few decades; however, they remain far from optimal. Currently, cancer research is focused on improving cancer diagnosis and treatment method...

Solid lipid nanoparticles (SLNs) are the effective lipid based colloidal carriers which were introduced as an alternative to the conventional carriers such as microemulsions, liposomes, microparticles and nanoparticles based on synthetic polymers or natural macromolecules. Typically they enhance the oral bioavailability of the low aqueous soluble drugs due to their potential to enhance gastroin...

Although the application of sorafenib, a small inhibitor of tyrosine protein kinases, to cancer treatments remains a worldwide option in chemotherapy, novel strategies are needed to address the low water solubility (< 5 μM), toxicity, and side effects issues of this drug. In this context, the use of nanocarriers is currently investigated in order to overcome these drawbacks. In this contributio...

INTRODUCTION The field of Novel Drug Delivery System is emerging at an exponential rate with the deep understanding gained in diversified fields of Biotechnology, Biomedical Engineering and Nanotechnology. Many of the recent formulation approaches utilize Nanotechnology that is the preparation of Nanosized structures containing the API. Nanotechnology, as defined by the National Nanotechnology ...

Cancer is a leading cause of death in many countries around the world. However, the efficacy of current standard treatments for a variety of cancers is suboptimal. First, most cancer treatments lack specificity, meaning that these treatments affect both cancer cells and their normal counterparts. Second, many anticancer agents are highly toxic, and thus, limit their use in treatment. Third, a n...

Magnetic nanoparticles that are currently explored for various biomedical applications exhibit a high propensity to minimize total surface energy through aggregation. This study introduces a unique, thermoresponsive nanocomposite design demonstrating substantial colloidal stability of superparamagnetic Fe3O4 nanoparticles (SPIONs) due to a surface-immobilized lipid layer. Lipid coating was acco...