Lipid-based nanostructures have garnered considerable interests over the last two decades, and achieved tremendous clinical success including first approval of a liposome (Doxil) for cancer therapy in 1995 recent COVID-19 mRNA lipid nanoparticle vaccines. Compared to liposomes which bilayer surrounding an aqueous core, nanoparticles with particle structure several attractive advantages encapsul...

Gadolinium-labelled nanocomplexes offer prospects for the development of real-time, non-invasive imaging strategies to visualise the location of gene delivery by MRI. In this study, targeted nanoparticle formulations were prepared comprising a cationic liposome (L) containing a Gd-chelated lipid at 10, 15 and 20% by weight of total lipid, a receptor-targeted, DNA-binding peptide (P) and plasmid...

The mechanisms of protection against respiratory syncytial virus (RSV) are poorly understood. Virus-like nanoparticles expressing RSV glycoproteins (eg, a combination of fusion and glycoprotein virus-like nanoparticles [FG VLPs]) have been suggested to be a promising RSV vaccine candidate. To understand the roles of alveolar macrophages (AMs) in inducing long-term protection, mice that were 12 ...

A lipid coated calcium phosphate (LCP) nanoparticle (NP) formulation was developed for efficient delivery of small interfering RNA (siRNA) to a xenograft tumor model by intravenous administration. Based on the previous formulation, liposome-polycation-DNA (LPD), which was a DNA-protamine complex wrapped by cationic liposome followed by post-insertion of PEG, LCP was similar to LPD NP except tha...

The reversible, temperature-dependent change in the permeability of a phospholipid bilayer has been used for controlling the diffusion rate of encapsulated molecular payload from liposomes. Liposomes were preloaded with a fluorescent dye and immobilized in calcium alginate hydrogel microparticles that also contained iron oxide nanoparticles. The composite microparticles were produced by a drop-...

Breast cancer, with around 2 million new cases in 2019, is the second most common cancer worldwide and leading cause of death among females. The aim this work to prepare a targeting nanoparticle through conjugation LinTT1 peptide, specific molecule p32 protein overexpressed by breast associated cells, on liposomes’ surface. This approach increases cytotoxic effects doxorubicin (DOX) sorafenib (...

Humans are the most crucial host of Salmonella Typhi as it has limited ability to reproduce outside human body. infections caused Typhoid fever which can be prevented with vaccines. This study aims develop an effective typhoid oral vaccine using a liposomal delivery system. Several studies showed that immunization AdhO36 protein from orally provides significant protection in inhibiting mice int...

The use of liposome as an adjuvant and a vaccine carrier has been cited previously in the literature. It has also been shown to be effective in enhancing the immunogenicity of vaccine candidates. BALB/c mice immunized subcutaneously with outer membrane protein (OMP) of Brucella abortus S19 vaccine strain entrapped in a commercial cationic liposome (S19-OMP-liposome) for vaccine delivery, showed...