New drug candidates increasingly tend to be poorly water soluble. One approach to increase their solubility is to convert the crystalline form of a drug into the amorphous form. Intrinsic dissolution testing is an efficient standard method to determine the intrinsic dissolution rate (IDR) of a drug and to test the potential dissolution advantage of the amorphous form. However, neither the Unite...

The present work manifests the results of the dynamic Young's modulus, E, after cold compaction and after sintering of partially dense copper and silver compacts. For both metals, the results show that E in the porous compacts depends not only on the attained density, but also on the samples' consolidation route. For porous metals, it is demonstrated that the normalized longitudinal sound wave ...

Abstract Compacts of microcrystalline cellulose were prepared at applied compression pressures 21, 32, 43, 53, and 64 MPa. subjected to elevated temperatures 125°C, 150°C, 175°C according a 5-min heating program. The effect these thermal treatments on compact volumes, densities, porosities, tensile strengths, weight loss was determined. There no change in the volumes compacts due most condition...

By analyzing spatio-temporal characteristics of short optical pulses diffusively transmitted through compacted granular materials, we reveal that powder compaction can give rise to strongly anisotropic light diffusion. Our disclosure represents a revision of the understanding of optics of powder compacts. Routes to material characterization and investigation of compression-induced structural an...

Purpose: To study the mechanical and dynamic swelling properties of grewia gum, evaluate its compression behaviour and determine the effect of drying methods on its properties. Methods: Compacts (500 mg) of both freeze-dried and air-dried grewia gum were separately prepared by compression on a potassium bromide (KBr) press at different pressures and subjected to Heckel analysis. Swelling studie...

Résumé. L’extraction d’itemsets fréquents est un sujet majeur de l’ECD et son but est de découvrir des corrélations entre les enregistrements d’un ensemble de données. Cependant, le support est calculé en fonction de la taille de la base dans son intégralité. Dans cet article, nous montrons qu’il est possible de prendre en compte des périodes difficiles à déceler dans l’organisation des données...