A novel liquisolid compact technique was used for soulbility enahncement of poorly water soluble drug carvedilol (CAR). CAR was dissolved in water miscible non volatile solvent and then adsorbed on a solid carrier which was later compacted with other excipient into a tablet. The tablets were characterized with respect to hardness, friability, disintegration and in-vitro dissolution profile. Eff...

Abstract Purpose The classic liquisolid technique is used to enhance the dissolution rate of poorly water-soluble drugs, but in some cases, it impossible reach desired using this alone. Therefore, a novel approach combination ball milling and technology was investigated improve for celecoxib. Methods First, celecoxib dispersed liquid vehicle (PEG 200), then ground mill 3 h. Other excipients, in...

Objective: The aim of this study was to investigate the potential a liquisolid system improve dissolution rate and bioavailability nebivolol hydrochloride. Methods: Solubility determined in different nonvolatile solvents finalize best vehicle having maximum solubility. compacts were prepared using Fujicalin as carrier material, Aerosil 200 coating Polyethylene glycol 400 liquid vehicle, Croscar...