Introduction: Non-invasive quantification of liver fat by Gradient echo (GRE) Technique is an interesting issue in quantitative MRI. Despite the numerous advantages of this technique, fat measurement maybe biased by confounding and effects. The aim of this study was to evaluate the GRE pulse sequences with different   and  weighting for liver fat quantification in patients with...

BACKGROUND Non-alcoholic and alcoholic fatty liver disease (NAFLD and AFLD, respectively) are major health problems, as patients with either condition can progress to hepatitis, fibrosis, and cirrhosis. Although histologically similar, key differences likely exist in these two models. For example, altered content of several vesicle trafficking proteins have been identified in AFLD, but their co...

Introduction The recent epidemic rise in metabolic syndrome/insulin resistance and type 2 diabetes are considered to be a result of a sedentary lifestyle combined with a high caloric diet. Earlier reports have consistently shown a link between a high fat intake, especially saturated fat, and insulin resistance [1]. More recently, the intake of simple carbohydrates, especially fructose, have bee...

Genetically engineered mouse models, such as double transgenic c-myc/TGFα mice, with specific pathway abnormalities might be more successful at predicting the clinical response of hepatocellular carcinoma (HCC) treatment. But a major drawback of the tumour models is the difficulty of visualizing endogenously formed tumours. The optimal imaging procedure should be brief and minimally invasive. M...

Background Iron quantification using T2* has become a routine noninvasive procedure for assessment of myocardium and liver in patients with regular transfusions. Cardiologists and cardiovascular radiologists are progressively measuring iron overload in the liver associated with myocardial overload. It is currently unknown if potential interference of high fat content in the liver may result in ...