locally advanced breast cancer

A VanderWalde W Ye P Frankel D Asuncion L Leong T Luu R Morgan P Twardowski M Koczywas R Pezner I B Paz K Margolin J Wong J H Doroshow S Forman S Shibata G Somlo

Patients with high-risk locally advanced/inflammatory and oligometastatic (≤3 sites) breast cancer frequently relapse or experience early progression. High-dose chemotherapy combined with peripheral stem cell rescue may prolong progression-free survival/relapse-free survival (PFS/RFS) and overall survival (OS). In this study, patients initiated high-dose chemotherapy with STAMP-V (carboplatin, ...

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Pegylated liposomal doxorubicin in combination with low-dose metronomic cyclophosphamide as preoperative treatment for patients with locally advanced breast cancer.

Journal: :Breast 2011

Silvia Dellapasqua Manuelita Mazza Debora Rosa Raffaella Ghisini Eloise Scarano Rosalba Torrisi Patrick Maisonneuve Giuseppe Viale Enrico Cassano Paolo Veronesi Alberto Luini Aron Goldhirsch Marco Colleoni

AIM To evaluate the role of pegylated liposomal doxorubicin with low-dose metronomic cyclophosphamide as primary systemic treatment in locally advanced breast cancer. PATIENTS AND METHODS The activity and safety of intravenous pegylated liposomal doxorubicin 20 mg sqm(-1) biweekly for eight courses in combination with metronomic cyclophosphamide 50 mg day(-1) orally were evaluated in 29 patie...

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