Lobstein disease is a severe disease characterized primarily by bone fragility which causes numerous fractures, especially in long bones. Multiple fracture of a bone will cause in time a deformity with consecutive functional impotence. The treatment for Lobstein disease in children must take into account both increasing bone strength and fracture prevention and treatment of possible fractures. ...

Concerns about bone health and potential fragility in children and adolescents have led to a high interest in bone densitometry. Pediatric patients with genetic and acquired chronic diseases, immobility, and inadequate nutrition may fail to achieve expected gains in bone size, mass, and strength, leaving them vulnerable to fracture. In older adults, bone densitometry has been shown to predict f...

OBJECTIVE To analyze the available evidence regarding the effect that corticosteroids have on the prevention of fat embolism syndrome after long bone fracture of the lower limbs or pelvic fracture. METHODS In March of 2007, we performed a search of various electronic databases, including Medline, the Excerpta Medica database, the Cochrane Library, the Latin American and Caribbean Health Scien...

INTRODUCTION The use of noninvasive, acoustic methods like ultrasonometry is becoming increasingly interesting in the quantitative assessment of fracture healing. A reliable measurement technique has been described using ultrasonic transducers placed across the fracture gap. Ultrasonic image aiming is useful for accurate transducers location, on both sides of the gap. The study was designed to ...

BACKGROUND Simple or unicameral bone cysts are common benign fluid-filled lesions usually located at the long bones of children before skeletal maturity. METHODS We performed demineralized bone matrix and iliac crest bone marrow injection combined with elastic intramedullary nailing for the treatment of simple bone cysts in long bones of 9 children with a mean age of 12.6 years (range, 4 to 1...

BACKGROUND Intramedullary nails are the primary choice for treating long bone fractures. However, complications following nail surgery including non-union, delayed union, and fracture of the bone or the implant still exist. Reducing nail stiffness while still maintaining sufficient stability seems to be the ideal solution to overcome the abovementioned complications. METHODS In this study, a ...

BACKGROUND The healing process of bone fracture requires a well-controlled multistage and sequential order beginning immediately after the injury. However, complications leading to nonunion exist, creating serious problems and costs for patients. Transforming growth factor-beta 1 (TGF-β1) and bone morphogenic protein 2 (BMP-2) are two major growth factors involved in human bone fracture healing...

INTRODUCTION The combination of traumatic brain injury (TBI) and long-bone fracture leads to increased formation of callus and mineral density in wild-type (WT) mice. However, this effect was not detected radiologically in leptin-deficient mice. Due to the complex interactions between hormonal and bone metabolism and the important role of leptin in this setting, our aim was to investigate morph...

The skeleton is part of the locomotor system which has a static and a dynamic biomechanical function. Bone mass, bone shape and bone structure influence these skeleton functions and also determine bone strength, an important determinant of fracture risk. They are mostly genetically determined and linked with body shape, structure and weight. This relationship is also genetically determined. Cha...