This study aims to explore the role of YKL-40 on permeability vessels in mice model and HDMECs histamine induces vascular hyperpermeability. The expression a HMC-1 was detected by RT-PCR western blot. experiment divided into different concentrations (10, 100 500ng/ml) alone,different concentrations(10, 500 ng/ml) YKL-40+100 μM histamine,500ng/ml YKL-40+100μM histamine+10 loratadine,100 alone bl...

the aim of the present work was to assess the feasibility of accononmc8-2ep/nf as a bioadhesive material for developing controlled release gastroretentive microsponges of loratadine. modified emulsion-solvent diffusion method was employed for the preparation of microsponges (f1-f9) based on 32 factorial design. the amount of ethyl cellulose (ec) and polyvinyl alcohol (pva) were selected as inde...

The purpose of the present study was to comparatively evaluate the effect of newer antihistamines on psychomotor functions in Indian population. Seventy five patient volunteers were included in the study. Volunteers were put into 5 groups based on the type of antihistamine prescribed. Group-1 volunteers included those who were prescribed no antihistamine, group-2 were prescribed first generatio...

Solubilizing properties of aqueous solutions of a series of surface-active agents, products of oxyethylation of cholic acid, were examined in the present study. The content of oxyethylated segments determined by means of the 1H NMR method enabled the verification of the molecular mass of surfactants along with the calculation of the structural hydrophilic-lipophilic balance (HLB), the solubilit...

OBJECTIVE To investigate immunomodulatory properties of 4 antihistamines available in Japan. METHOD Isolated peripheral blood T cells from healthy volunteers were preincubated with cetirizine, loratadine, olopatadine, or fexofenadine for 30 minutes and then stimulated with interleukin (IL)-1 2 or IL-4 to skew immune response towards type 1 or type 2 helper T cells. RNA was extracted 6 hours l...

To study the response of the maxillary sinus to histamine provocation, we performed a double-blind, randomized, crossover trial during which nonallergic subjects without symptoms of rhinitis (n = 25) received either 10 mg loratadine or placebo once daily for a week and then underwent nasal challenge with histamine (3, 10, and 30 mg/ml) followed, 24 h later, by a maxillary sinus challenge while ...