INTRODUCTION There is an urgent need for health authorities across Europe to fully realize potential savings from increased use of generics to sustain their healthcare systems. A variety of strategies were used across Europe following the availability of generic losartan, the first angiotensin receptor blocker (ARB) to be approved and marketed, to enhance its prescribing vs. single-sourced drug...

-Angiotensin type 2 receptor-mediated effects of angiotensin II appear to counteract many of the effects mediated via the angiotensin type 1 receptor. Compound 21 (C21), a selective angiotensin type 2 receptor agonist, has demonstrated beneficial effects on cardiac function after myocardial infarction in rodents. We hypothesized that C21 alone or in combination with an angiotensin type 1 recept...

This study investigated the role of angiotensin II receptor blocker in atrial remodeling in rats with atrial fibrillation (AF) induced by a myocardial infarction (MI). MIs were induced by a ligation of the left anterior descending coronary artery. Two days after, the rats in the losartan group were given losartan (10 mg/kg/day for 10 weeks). Ten weeks later, echocardiography and AF induction st...

BACKGROUND & AIMS The potential use of losartan, an angiotensin II type 1 receptor blocker, in the treatment of portal hypertension is still under debate. This randomized controlled trial compared the effects of losartan vs. propranolol on portal and systemic hemodynamics in patients with cirrhosis. METHODS Twenty-seven compensated patients were randomized to receive losartan 25 mg/day (n = 1...

Objective: The objective of this study is to compare the effectivity of captopril, losartan, and amlodipine on hypertension in rat model of gentamicin-induced renal failure. Methods: Adult male Wistar rats weighing 175-225 g are used. The rats were divided into 5 groups: negative control, positive control, captopril 120 mg/kg bw, losartan 20 mg/kg bw, and amlodipine 10 mg/kg bw group. All group...

33.3% of candesartan patients received 76% or more of the target dose vs 78.0% of losartan patients. For the model using 150 mg of losartan as the target dose, 33.3% of candesartan patients received 25% or more of the target dose vs 0.2% of losartan patients. The actual mean (SD) dose of candesartan was 18 (11) mg (56% [36%] of the target dose of 32 mg) and of losartan, 53 (26) mg (106% [52%] o...

OBJECTIVE To study the effects of losartan and atenolol on glucometabolic parameters in nondiabetic hypertensive patients. MATERIALS AND METHODS In a prospective, open-label, parallel group study, nondiabetic patients with mild to moderate hypertension were randomized to either losartan (titrated from 50 to 100 mg/day, n = 20) or atenolol (titrated from 25 mg to 100 mg/day, n = 20) for period...

Treatment of rats with streptozotocin (STZ, 45mg/kg, i.v.,single dose) produced cardinal symptoms of diabetes mellitus including hyperglycemia, hypoinsulinemia and increase in blood pressure. Treatment with losartan--an angiotensin (AT1) receptor antagonist, 2 mg/kg, po for 6 weeks decreased the blood glucose levels by 16.5%. There was 190% increase in AUCglucose and 59.4% decrease in AUCinsuli...

Fosinopril, ramipril and losartan significantly decreased the duration (sec) of immobility in forced swim test and were comparable to amitriptyline. The duration of immobility were significantly decreased in fosinopril, ramipril and losartan in the tail suspension test and were comparable to amitriptyline. Only losartan significantly increased the rearing number of entries, time spent (sec) in ...

Endoplasmic reticulum (ER) stress is increasingly identified as modulator of fibrosis. Losartan, an angiotensin II receptor blocker, has been widely used as the first choice of treatment in chronic renal diseases. We postulated that anti-fibrotic effect of losartan is mediated through inhibition of ER stress via SIRT1 (silent mating type information regulation 2 homolog 1) hemeoxygenase-1 (HO-1...