Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification of their pharmacologic properties predated the cloning of their classical receptors and the development of drugs that modify their synthesis and actions. Recent studies have ...

In Aplysia, long-term sensitization (LTS) occurs concurrently with a suppression of feeding. At the cellular level, the suppression of feeding is accompanied by decreased excitability of decision-making neuron B51. We examined the contribution of voltage-gated Na+ and K+ channels to B51 decreased excitability. In a pharmacologically isolated Na+ channels environment, LTS training significantly ...

The article introduces an extension of the well-known conformance relation ioco on labeled transition systems (LTS) with refused inputs and forbidden actions. This extension helps to apply the usual formal testing theory based on LTS models to incompletely specified systems, which are often met in practice. Another topic concerned in the article is compositional conformance. More precisely, we ...

We reported a rat model of necrotizing enterocolitis by injecting platelet-activating factor (PAF) into the mesenteric vascular bed, and suggested that leukotrienes (LT) are secondary mediators. The present study, using isolated, buffer-perfused rat small intestine, shows: Isolated, perfused small intestine synthesizes LTs in response to PAF. Leukotriene C4 (LTC4) was the predominant LT release...

A new procedure for the calibration of an articulated arm coordinate measuring machine (AACMM) is presented in this paper. First, a self-calibration algorithm of four laser trackers (LTs) is developed. The spatial localization of a retroreflector target, placed in different positions within the workspace, is determined by means of a geometric multilateration system constructed from the four LTs...

Combilex is a high quality pronunciation lexicon, aimed at speech technology applications, that has recently been released by CSTR. Combilex benefits from several advanced features. This paper evaluates one of these: the explicit alignment of phones to graphemes in a word. This alignment can help to rapidly develop robust and accurate letter-to-sound (LTS) rules, without needing to rely on auto...

We introduce G-relative-pushouts (GRPO) which are a 2-categorical generalisation of relative-pushouts (RPO). They are suitable for deriving labelled transition systems (LTS) for process calculi where terms are viewed modulo structural congruence. We develop their basic properties and show that bisimulation on the LTS derived via GRPOs is a congruence, provided that sufficiently many GRPOs exist...

Eosinophils have long been considered to play solely crucial role in the pathogenesis of aspirin-induced asthma, however increasing evidence suggest that the bronchial epithelium is also involved in the initiation and maintenance of allergic inflammation. Epithelial cells and eosinophils retained within airways interact reciprocally to mount and sustain inflammatory response. Recently, we have ...

Observations in subtropical regions show that stratiform low cloud cover is well correlated with the lower-troposphere stability (LTS), defined as the difference in potential temperature between the 700-hPa level and the surface. The LTS can be regarded as a measure of the strength of the inversion that caps the planetary boundary layer (PBL). A stronger inversion is more effective at trapping ...

BACKGROUND The Laryngeal Tube Suction Disposable (LTS-D) and the Supreme Laryngeal Mask Airway (SLMA) are second generation supraglottic airway devices (SADs) with an added channel to allow gastric drainage. We studied the efficacy of these devices when using pressure controlled mechanical ventilation during general anesthesia for short and medium duration surgical procedures and compared the o...