Treatment of von Willebrand disease typically requires multiple infusions of von Willebrand factor (VWF)/factor VIII (FVIII) concentrate. Accumulation of FVIII is a clinical concern due to potential risk for thromboembolism. This study sought to determine whether VWF/FVIII concentrate of high VWF:FVIII ratio can prevent FVIII accumulation. VWF-deficient knockout mice received four 150 IU/kg VWF...

UNLABELLED We have prospectively evaluated the biologic response to desmopressin (DDAVP) in 28 children with type 2 von Willebrand disease (VWD) in correlation with the phenotype and the molecular defect of VWF. The diagnosis of VWD type 2 was mainly based on VWF functional parameters and/or an aberrant VWF multimer pattern. Seventeen different mutations were identified (6 of them novel). No re...

population dynamic parameters of red mullet, mullus barbatus (n=592) caught by trawlers operating in arzew gulf (algeria) in the western mediterranean were studied. samples were collected between february 2013 and january 2014. females ranged from 10.9-23.2 cm in total length and 12-149.2 g in weight whereas males length was comprised between 12.6 and 19.7 cm and weight between 21.3 and 99.9 g....

purpose: to compare the effect of different deviation measurement techniques and different lens powers on gradient accommodative convergence to accommodation (ac/a) ratio. methods: we randomly selected 78 eligible students of different majors from zahedan university of medical sciences. following retinoscopy for refractive errors, alternate prism cover test, von graefe and maddox rod without ad...

one of the most controversial problems in western epistemology is the division of propositions into analytic and synthetic. this division drew the attention of many proponents and opponents and faced many objections. one the most important objections which if valid enough, can destroy the basis of this division and resulting epistemological consequences is the of relativity of both analytic as ...