We studied the feasibility of evaluating tumor control probability (TCP) reductions for tumor motion beyond planned gated radiotherapy margins. Tumor motion was determined from cone-beam CT projections acquired for patient setup, intrafraction respiratory traces, and 4D CTs for five non-small cell lung cancer (NSCLC) patients treated with gated radiotherapy. Tumors were subdivided into 1 mm sec...

PURPOSE Proton radiotherapy, with the ability to confine the dose at desired depth, can potentially benefit lung tumor patients by significantly sparing the healthy lung tissue. However, the superior proton dose distribution could be affected by tumor shrinkage due to the quick response and by motion especially related to the respiration. Thus the treatment should be frequently verified and be ...

Accurate lung tumor tracking in real time is a keystone to image-guided radiotherapy of lung cancers. Existing lung tumor tracking approaches can be roughly grouped into three categories: (1) deriving tumor position from external surrogates; (2) tracking implanted fiducial markers fluoroscopically or electromagnetically; (3) fluoroscopically tracking lung tumor without implanted fiducial marker...

PurposesWith the recent clinical implementation of MR-guided linear accelerators, a large amount real-time planar MR images have been acquired during lung cancer treatment as standard care. In this study, associations among tumor, diaphragm, and external skin movement were studied based on cine imaging entire duration each fraction.Methods MaterialsThis retrospective study used 181,798 image fr...

BACKGROUND Tumor motion during radiotherapy delivery can substantially deteriorate the target dose distribution. A promising method to overcome this problem is dynamic multi-leaf collimator (DMLC) tracking. The purpose of this phantom study was to integrate a wired electromagnetic (EM) transponder localization system with DMLC tracking and to investigate the geometric accuracy of the integrated...

OBJECTIVES To investigate the impact of respiratory motion on localization, and quantification of lung lesions for the Gross Tumor Volume utilizing a fully automated Auto3Dreg program and dynamic NURBS-based cardiac-torso digitized phantom (NCAT). METHODS Respiratory motion may result in more than 30% underestimation of the SUV values of lung, liver and kidney tumor lesions. The motion correc...

Title of Document: MULTIVARIATE STATISTICAL TECHNIQUES FOR ACCURATELY AND NONINVASIVELY LOCALIZING TUMORS SUBJECT TO RESPIRATIONINDUCED MOTION Kathleen T. Malinowski, Doctor of Philosophy, 2012 Directed By: Warren D. D’Souza, Associate Professor, Fischell Department of Bioengineering and Director, Department of Medical Physics Tumors in the lung, liver, and pancreas can move considerably with n...