BACKGROUND Somatostatin analogue-based radionuclide therapy with (177)Lu-DOTATATE is an important treatment option for patients with advanced neuroendocrine tumours overexpressing somatostatin receptors. In addition to the kidneys, the bone marrow is a major dose-limiting organ. The correlation between developed haematological toxicity and absorbed dose to the bone marrow is poor, which indicat...

PURPOSE OF THE STUDY With rapid development in the field of nuclear medicine therapy, radiation safety of the personnel involved in synthesis of radiopharmaceuticals has become imperative. Few studies have been done on estimating the radiation exposure of personnel involved in the radio labeling of 177Lu-compounds in western countries. However, data from the Indian subcontinent are limited. We ...

2014 The internal friction and the dynamic modulus have been measured between 4.2 and 470 K in the system 03B1-LuH(D)x, with x = 0 to 0.2. In well annealed specimens, an (H)-peak is observed at 215-225 K, which has a linearly x-dependent amplitude and exhibits an isotope effect on its activation energy and relaxation time. It is attributed to a Snoek-like relaxation of H-H pairs reorienting in ...

objective(s): in this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. materials and methods: lu-177 of 2.6-3 gbq/mg specific activity was obtained by irradiation of natural lu2o3 sample with thermal neutron flux of 4 × 1013 n.cm-2.s-1. the product was converted into chloride form which was further used for labeling of 177lu-phytate complex and che...

We evaluated observer agreement for 68Ga-DOTATATE PET/CT interpretations in patients with neuroendocrine tumor (NET). METHODS 68Ga-DOTATATE PET/CT was performed on 50 patients with known or suspected NET of the small bowel (n = 19), pancreas (n = 14), lung (n = 4), or other location (n = 13). The images were reviewed by 7 observers, who used a standardized interpretation approach. The observe...

BACKGROUND Radiation-induced nephropathy is still dose limiting in radionuclide therapy of neuroendocrine tumors. We investigated the nephroprotective potential of the angiotensine converting enzyme inhibiting drug enalpril after [177Lu]-DOTATATE therapy in a murine model of radiation-induced nephropathy by renal scintigraphy. At first, the appropriate therapy activity to induce nephropathy was...

BACKGROUND Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms derived from endocrine stem cells.These tumors are characterized by overexpression of somatostatin receptors (SSTR), which is utilized for imaging using SSTR analogs. Peptide receptor radionuclide therapy (PRRT) somatostatin analogs labeled with 90Y and 177Lu in neuroendocrine tumors (NETs) results in symptomatic imp...

We report herein the synthesis and characterization of a lutetium dialkyl complex supported by a multidentate, anilido-pyridine-imine ligand and its subsequent transformation into an unprecedented cationic monoalkyl derivative.