tilmicosin (tlm) is an important antibiotic in veterinary medicine with low bioavailability and safety. this study aimed to formulate and evaluate physicochemical properties, storage stability after lyophilization and antibacterial activity of three tlm-loaded lipid nanoparticles (tlm-lnps) including solid lipid nanoparticles (slns), nanostructured lipid carriers (nlcs) and lipid-core nanocapsu...

Topical administration of non-steroidal anti-inflammatory drugs (NSAIDs) is generally considered safer than oral administration, although the former can occasionally induce cutaneous irritation. We hypothesized that the cutaneous irritation by topical NSAIDs might be suppressed by trehalose, which has protective effects on biological membranes. Using the three-dimensional cultured human skin mo...

the aim of the present study was to prepare an oral tablet from liquid yogurt by reforming the physical properties for easy transportation, long-term storage and also as a complementary dairy product in case of nutrient deficiency. the liquid fresh yogurt was lyophilized at -40°c and 0.03 mtor pressure. the dry powder was homogenized by a 12 mesh size sieve. some tests such as carr’s compressib...

objective anti-rh d igg is used for the prevention of anti-d antibody production in rh- individuals who have been exposed to rh+ red blood cells. the stability of igg preparations as a solution is low, with a shelf life of a year or more. formulation of anti-rh d igg as a lyophilized preparation would decrease its degradation rate and increases its shelf life. the objective of this study was to...

Nanoparticle formulations have been widely used in the drug delivery field. The majority of published articles dealing with nanoparticle formulations have focused on the use of freshly prepared nanoparticles, but not many deal with scale-up production of nanoparticles and their long-term preservation by freeze-drying. To date, little information is available on an effective freeze-drying proces...