نتایج جستجو برای: lyophilized formulation

تعداد نتایج: 113809  

Journal: :NIPPON SUISAN GAKKAISHI 1963

2004
E. C. M. Cabral R. L. Zollner H. A. Santana

This work presents results of the preparation and characterization of small unilamellar liposomes for entrapping allergenic proteins extracted from the biomass of Dreschlera (Helminthosporium) monoceras cultivated by solid fermentation. Protein was entrapped by the dehydration-rehydration method, using lyophilization of preformed liposomes in order to prevent their degradation The reconstitutio...

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2000
F Frézard M S Michalick C F Soares C Demicheli

The antimonial drug, meglumine antimoniate, was successfully encapsulated in dehydration-rehydration vesicles and in freeze-dried empty liposomes (FDELs). High encapsulation efficiencies (from 28 to 58%) and low weight ratios of lipids to encapsulated antimony (from 1:0.15 to 1:0.3) were achieved. These formulations, contrary to those obtained by conventional methods, can be stored as intermedi...

Journal: :European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009
Robhash Kusam Subedi Keon Wook Kang Hoo-Kyun Choi

Solid lipid nanoparticles (SLN) loaded with doxorubicin were prepared by solvent emulsification-diffusion method. Glyceryl caprate (Capmul)MCM C10) was used as lipid core, and curdlan as the shell material. Dimethyl sulfoxide (DMSO) was used to dissolve both lipid and drug. Polyethylene glycol 660 hydroxystearate (Solutol)HS15) was employed as surfactant. Major formulation parameters were optim...

Journal: :Acta pharmaceutica 2016
Ahmed Refaat Magda Sokar Fatma Ismail Nabila Boraei

Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared using the hot melt extrusion technique and utilizing three lipid carriers: Compritol, Precirol a...

1998
Shela Gorinstein Marina Zemser Moshe Weisz Shmuel Halevy Olga Martin-Belloso Simon Trakhtenberg

It is an established fact that moderate consumption of alcoholic beverages leads to some positive biochemical changes in blood that are widely regarded as indicators of improved prevention of atherosclerosis. However, at present, there are different opinions regarding the biologically active compounds of alcoholic beverages that bring about these changes. This experiment was conducted on 60 mal...

Journal: :European cells & materials 2010
J Alfredo Santibáñez-Salgado J Raúl Olmos-Zúñiga María Pérez-López Carlos Aboitiz-Rivera Miguel Gaxiola-Gaxiola Rogelio Jasso-Victoria Avelina Sotres-Vega Matilde Baltazares-Lipp Diana Pérez-Covarrubias Jaime Villalba-Caloca

A variety of patch materials has been used to close large atrial septal defects (ASD). Autologous pericardium and glutaraldehyde-preserved bovine pericardium are the most used. Lyophilized bovine pericardium has not been tested inside the cardiovascular system. The aim of this work was to study the behaviour and effectiveness of lyophilized glutaraldehyde-preserved bovine pericardium in ASD clo...

2000
W. J. Sichina

The production of many new drugs requires that the active material first be dissolved in water and then freeze-dried or lyophilized in order to generate a compound which is easily ingested and which also has a pleasing or pharmaceutically elegant appearance. The lyophilization process involves cooling an aqueous formulation to subambient temperatures and then pulling a vacuum to drive off the f...

Journal: :Fungal Genetics Reports 1964

Journal: :Acta poloniae pharmaceutica 2005
Mohamed Mahmoud Nounou Labiba Khalil El-Khordagui Nawal Khalafallah

Possible leakage of 5-fluorouracil from stable plurilamellar vesicles was monitored during storage of the liposomal concentrates, gels and lyophilized powders. Changes in release profile of dibucaine were taken as indicator of instability. Release profiles were obtained using the dialysis technique for a freshly prepared liposomal concentrate, gel or reconstituted lyophilized powder (zero time)...

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