BACKGROUND After implementation of routine infant MenC vaccination, MenB remains a serious cause of meningococcal disease, yet to be targeted by vaccination programs in several countries. This study (NCT01339923) investigated the immunogenicity and safety of MenC CRM-conjugated vaccine (MenC-CRM) concomitantly administered with MenB vaccine (4CMenB). METHODS Infants (N=251) were randomised 1:...

Linezolid is often the drug of last resort for serious methicillin-resistant Staphylococcus aureus (MRSA) infections. Linezolid resistance is mediated by mutations in 23S rRNA and genes for ribosomal proteins; cfr, encoding phenicol, lincosamide, oxazolidinone, pleuromutilin, and streptogramin A (PhLOPSA) resistance; its homologue cfr(B); or optrA, conferring oxazolidinone and phenicol resistan...

Efavirenz (Sustiva) is a potent and specific inhibitor of the HIV-1 reverse transcriptase and is approved for the treatment of HIV infection. The metabolism of efavirenz in different species has been described previously. Efavirenz is primarily metabolized in rats to the glucuronide conjugate of 8-OH efavirenz. Electrospray ionization-liquid chromatography/mass spectrometry analyses of bile sam...

Cell-surface proteoglycans have been implicated in cell responses to growth factors, extracellular matrix, and cell adhesion molecules. M12, one of the most abundant membrane-associated proteoglycans in the adult rat brain, is a approximately 65 kDa glycosylphosphatidylinositol-linked protein that bears heparan sulfate chains (Herndon and Lander, 1990). To assess its identity, M12 was purified ...

26 Linezolid is often the drug of last resort for serious methicillin-resistant Staphylococcus aureus 27 (MRSA) infections. Linezolid resistance is mediated by mutations in 23S rRNA and genes for 28 ribosomal proteins, cfr encoding phenicol, lincosamide, oxazolidinone, pleuromutilin and 29 streptogramin A (PhLOPS A) resistance, its homolgue cfr(B) or optrA conferring oxazolidinone 30 and phenic...

PurposeSurvival after lung transplantation (LTx) still remains limited by chronic allograft dysfunction (CLAD). Prior studies showed an association between graft cellular expression of the checkpoint HLA-G and acceptance, whereas conversely, soluble (sHLA-G) in plasma/BAL was associated with acute rejection. We investigated whether plasma levels extra-vesicular (EVs)-bound could predict CLAD.Me...

In this paper, we present a new approach to subpixel infrared (IR) emitter detection in VIIRS mid-wave (MWIR) bands M12–M13 at night, based on the presence of tightly clustered background diagonal full granule scattergrams M12 versus M13 radiances. This is found universally night-time data collected worldwide. The feature absent during day due solar reflectance. existence attributed close spaci...