Sensitive measurement of biomarkers is of great importance in biomedical research, disease monitoring, and clinical diagnosis. In particular, much attention has been recently directed to rapid and sensitive diagnostics in the point-of-care (POC) settings. For instance, cardiac biomarkers and diabetes biomarkers have been detected with POC devices that allow onthe-spot diagnosis, thereby facilit...

2010 WILEY-VCH Verlag Gmb Magnetic beads with functionalized surfaces are widely used as molecule carriers or labels for single molecule studies, cell manipulation, and biomagnetic sensing. For this reason manipulation at the nanoscale of surface functionalized magnetic beads in suspension is of paramount importance in biotechnology, nanochemistry, and nanomedicine as it leads to a precise cont...

We demonstrate a highly sensitive nanoparticle and virus detection method by using a thermal-stabilized reference interferometer in conjunction with an ultrahigh-Q microcavity. Sensitivity is sufficient to resolve shifts caused by binding of individual nanobeads in solution down to a record radius of 12.5 nm, a size approaching that of single protein molecules. A histogram of wavelength shift v...

Spatial fluorescence cross-correlation spectroscopy is a rarely investigated version of fluorescence correlation spectroscopy, in which the fluorescence signals from different observation volumes are cross-correlated. In the reported experiments, two observation volumes, typically shifted by a few microm, are produced, with a spatial light modulator and two adjustable pinholes. We illustrated t...

Semiconductor nanowires and other semiconducting nanoscale materials configured as field-effect transistors have been studied extensively as biological/chemical (bio/chem) sensors. These nanomaterials have demonstrated high-sensitivity from one- and two-dimensional sensors, although the realization of the ultimate pointlike detector has not been achieved. In this regard, nanoscale p-n diodes ar...