OBJECTIVE Variation in the catechol-O-methyltransferase (COMT) val(158)met polymorphism has been associated with executive cognition and working memory, presumably mediated by the prefrontal cortex. Here, we extend these observations by examining two measures of cognitive function, lapses in attention and visuo-spatial-motor speed of processing, in both the drug-free state and after administrat...

class SensevalData (s: String ) extends Agent [String , Context ] { val file = new File(s) val trainDataReader = new STAXSensevalDataReader (file); val samples : List[ Ambiguity ] = trainDataReader . getAmbiguities . toList val words : java.util.List[ String ] = trainDataReader . getWords def process ( input : java.util.List[ Annotation [ String ]]) = samples .map( asAnnotation (_)) def asAnnot...

Pseudomonas putida produces two lipoamide dehydrogenases, LPD-glc and LPD-val. LPD-val is specifically required as the lipoamide dehydrogenase of branched-chain keto acid dehydrogenase and LPD-glc fulfills all other requirements for lipoamide dehydrogenase. Both proteins are dimers with one FAD per subunit. LPD-glc has an absorption maximum at 455 nm, but LPD-val has a maximum at 460 nm. Compar...

BACKGROUND Poly (ADP-ribose) polymerase-1 (PARP-1) plays critical roles in the detection and repair of damaged DNA, as well as cell proliferation and death. Numerous studies have examined the associations between PARP1 Val762Ala (rs1136410 T>C) polymorphism and cancer susceptibility; nevertheless, the findings from different research groups remain controversial. METHODS We searched literature...

Cilnidipine (Cil), which is an L-/N-type calcium channel blocker (CCB), has been known to provide renal protection by decreasing the activity of the sympathetic nervous system (SNS) and the renin-angiotensin system. In this study, we compared the effects of the combination of Cil and amlodipine (Aml), which is an L-type CCB, with an angiotensin (Ang) II receptor blocker on diabetic cardiorenal ...

Background Systemic Lupus Erythematosus (SLE) is an autoimmune disease with a variety of manifestations, one which immune thrombocytopenia (ITP). Immune has been reported in 7-40% SLE patients [1,2]. Objectives To determine the prevalence ITP and identify risk factors that correlate ITP. Methods Retrospective case-control study. 407 medical records were reviewed: 34 diagnosed (cases) age- sex-m...

Both the Valsartan (VAL) and Olmesartan medoxomil (OLM) are widely prescribed anti-hypertensive agents with angiotensin II type I receptor antagonistic activity. VAL OLM of BCS class drugs having a low variable oral bioavailability. Recrystallization from different organic solvents improved its aqueous solubility thereby in vitro dissolution properties. In present investigation, tablets contain...