We used adaptive umbrella sampling on a modified version of the roll angle to simulate the bending of DNA dodecamers. Simulations were carried out with the AMBER and CHARMM force fields for 10 sequences in which the central base pair step was varied. On long length scales, the DNA behavior was found to be consistent with the worm-like chain model. Persistence lengths calculated directly from th...

J Bone Joint Surg [Br] 2008;90-B:1473-6. Received 3 January 2008; Accepted after revision 27 June 2008 Our aim in this prospective radiological study was to determine whether the flexibility rate calculated from radiographs obtained during forced traction under general anaesthesia, was better than that of fulcrum-bending radiographs before corrective surgery in predicting the extent of the avai...

Nucleic acids are highly charged polyanionic molecules; thus, the ionic conditions are crucial for nucleic acid structural changes such as bending. We use the tightly bound ion theory, which explicitly accounts for the correlation and ensemble effects for counterions, to calculate the electrostatic free energy landscapes for DNA helix bending. The electrostatic free energy landscapes show that ...

Carbon-fiber reinforced plastic (CFRP) is ideal for bridge reinforcement due to its high strength, light weight, and corrosion resistance. Studies on the friction loss of CFRP tendons in a bending state form an important part advancing application materials external prestressing strengthening technology. To understand magnitude variation interfacial prestressed under conditions, 12 single-bendi...

We have used circular permutation assays to determine the extent and location of the DNA bend induced by the DNA binding domain of human wild type p53 (p53DBD) upon binding to several naturally occurring DNA response elements. We have found that p53DBD binding induces axial bending in all of the response elements investigated. In particular, response elements having a d(CATG) sequence at the ju...

In this paper, we investigate the gravitational bending angle due to Casimir wormholes, which consider energy as source. Furthermore, some of these wormholes regard Generalized Uncertainty Principle (GUP) corrections energy. We use Ishihara method for Jacobi metric, allows us study light and massive test particles finite distances. Beyond uncorrected source, many GUP corrections, namely, Kempf,...