BACKGROUND Androgenetic alopecia (AGA) is the most commonly encountered baldness pattern in men. Epicardial fat tissue is found on the cardiac surface between the myocardium and visceral pericardium. Both AGA and epicardial fat thickness (EFT) are related to coronary artery disease, which is also reflected by an increase in carotid intima media thickness (CIMT). OBJECTIVE The purpose of this ...

Male-pattern hair loss (MPHL) is a highly heritable and prevalent form of loss. While genome-wide association studies (GWAS) have provided insights into the contribution common genetic variants to MPHL etiology, relevance rare unclear. In this study, we tested for coding etiology based on exome data 72,469 men from UK Biobank. We performed SKAT-O GenRisk gene-based analyses as well single-varia...

Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P<5 × 10-8, METAL) of which 23 have not been reported previously....

Finasteride (a synthetic 5-alpha-reductase inhibitor) is used for the treatment of male pattern baldness and benign prostatic hyperplasia. There have been few reports on pregnancy outcomes after paternal exposure to finasteride either prior to or during pregnancy. Nineteen cases with documented paternal exposure to finasteride either prior to or during pregnancy were identified through the Kore...

Finasteride (a synthetic 5-alpha-reductase inhibitor) is used for the treatment of male pattern baldness and benign prostatic hyperplasia. There have been few reports on pregnancy outcomes after paternal exposure to finasteride either prior to or during pregnancy. Nineteen cases with documented paternal exposure to finasteride either prior to or during pregnancy were identified through the Kore...

This preliminary study focuses on the effect of a topical application of herbal Hair Loss Cream, in the reduction of hair loss and promotion of new hair growth in men and women. Twenty subjects (15 men and 5 women), with varying levels of hair loss, were enrolled in this six month study. This study indicates that herbal Hair Loss Cream is effective in reducing hair loss in both men and women: 5...

IMPORTANCE OF THE FIELD Androgenetic alopecia affects up to 80% of males by the age of 80. The synonym 'male-pattern hair loss' highlights the fact that hair loss occurs in a defined and reproducible pattern. Hair loss results in reduced self esteem, loss of confidence and anxiety in affected men. An effective treatment for hair baldness would be desirable. AREAS COVERED IN THIS REVIEW In and...