Increased mammographic breast density is considered an intermediate marker of breast cancer risk. Physical activity is believed to reduce breast cancer risk; however, its effect on breast density is not well understood. We studied the association between recreational physical activity and mammographic characteristics of the breast among a population of premenopausal and postmenopausal women enr...

High mammographic density confers a significantly increased risk of breast cancer. As it is relatively common in the normal population the risk of cancer attributable to increased mammographic density could potentially account for an important percentage of total BCa cases. The underlying cause for high mammographic density and its association with increased BCa risk and progression is unknown....

A methodology is introduced for the automated assessment of structural changes of breast tissue in mammograms. It employs a generic machine learning framework and provides objective breast density measures quantifying the specific biological effects of interest. In several illustrative experiments on data from a clinical trial, it is shown that the proposed method can quantify effects caused by...

OBJECTIVE we investigated effects of different regimens of hormone replacement therapy (HRT) on mammographic density. METHODS ninety-five postmenopausal women, who were on different HRT regimens and completed their 4-year mammographic follow-up, were included into this retrospective and comparative study. Twenty-three of these women, who had surgical menopause, received conjugated equine estr...