نتایج جستجو برای: mannich bases
تعداد نتایج: 67708 فیلتر نتایج به سال:
Mannich bases are beta-amino ketone-carrying compounds that the end products of reaction. The reaction is essential in synthesis nitrogen-containing compounds. reaction, a nucleophilic addition forms carbon-carbon bonds, employed numerous natural products, drugs and other There several aminoalkyl chain bearing with high curative value, such as fluoxetine, atropine, ethacrynic acid, trihexypheni...
Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbonylhydrazones (1a-e) with several primary amines. The synthesis of 4-amino-5-(4-chlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (13)...
The sphingoid base backbones of sphingolipids (sphingosines, sphinganines, 4-hydroxysphinganines and others) are highly bioactive species directly and-in most cases-as their metabolites, the N-acyl-sphingoid bases (ceramides) and sphingoid base 1-phosphates. The complexity of these compounds affords many opportunities to prepare synthetic analogs for studies of sphingolipid metabolism and the f...
The use of 4-amino-5-benzyl-4H-[1,2,4]triazole-3-thiol (1) as a precursor to synthesize some new biologically active heterocycles has been found to be effective. Condensation of 1 with appropriate aldehydes gave the new Schiff bases 2a, b, which either by cyclization with thioglycolic acid gave 3a, b, or by Mannich reaction using morpholine gave 4a, b. Reaction of 1 with different halogen compo...
Neuropathic pain comprises a variety of painful conditions, including post amputation pain, painful neuropathies, post traumatic neuralgia, and others. So far, multiple factors responsible for development of neuropathic pain have been identified: metabolic diseases (e.g., diabetes), neuronal tissue injuries caused by toxicological factors or mechanical damage to the spinal cord, and others (Nic...
Uma série de novas Bases de Mannich (HL1-HL13) derivadas da 2-hidroxi-1,4-naftoquinona (lausona), benzaldeídos substituídos [C 6 H 2 RRRC(O)H] e várias aminas primárias (NH 2 R, R = n-butil, benzil, alil, 2-furfuril) e seus complexos de Cu, [Cu(L1) 2 ]-[Cu(L13) 2 ], foram sintetizados e caracterizados por métodos analíticos e espectroscópicos. As estruturas dos complexos 1 (R = R = R = H; R = B...
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