In very deep-submicron very large scale integration (VLSI), manufacturing steps involving chemical-mechanical polishing (CMP) have varying effects on device and interconnect features, depending on local characteristics of the layout. To reduce manufacturing variation due to CMP and to improve performance predictability and yield, the layout must be made uniform with respect to certain density c...

Concurrent engineering (CE) has emerged as an essential design principle that facilitates rapid and efficient product development that is necessary to survive in today’s fiercely competitive environment. However, the lack of tools that address design team formulation and proper design task assignment in CE has made its application an immense challenge. In this article we explicitly address this...

car manufacturing industry is considered one of the major national industries, which due to its increasing product, particularly in recent years, has played a crucial role in the economy of the country, and still continues to do so. with the development of manufacturing capacity in the car industry, a relative competition is being witnessed among the manufacturers, which calls for the considera...

Airaksinen, S.T.T., 2005. Role of excipients in moisture sorption and physical stability of solid pharmaceutical formulations. Dissertationes bioscientiarum molecularium Universitatis Helsingiensis in Viikki, 20/2005, pp. 57, ISBN 952-10-2733-9 (print) ISBN 952-10-2734-7 (pdf) ISSN 1795-7079 The interaction of moisture with pharmaceutical solids is crucial to an understanding of water-based pro...

ABOUT THE AUTHORS Deliang Zhou, Ph.D., is a principal pharmaceutical scientist in Oral Drug Products, Manufacturing Science & Technology at Abbott Laboratories. He may be reached at [email protected]. Yihong Qiu, Ph.D., is a research fellow and associate director in Global Pharmaceutical Regulatory Affairs CMC, Global pharmaceutical R&D at Abbott Laboratories. He may be reached at qiu.yih...

Abstract— In order to determine necessary time to reach a desired quota, the manager of a flexible batch manufacturing system must know the best method of scheduling the factory. To determine a sub-optimal schedule, we first create a model of the factory. This model is used to simulate the factory. Using this simulation and an integer programming formulation, we determine a scheduling algorithm...

A major challenge in the development of orally disintegrating tablets (ODTs) is to achieve a good balance between tablet hardness and disintegration time. In this study, an advanced method was demonstrated to improve these opposing properties in a molded tablet using a one-step procedure that exploits the swelling induced by microwave treatment. Wet molded tablets consisting of the delta form o...

We consider a manufacturing scheduling problem in which the sequence of products to be manufactured has to be determined so as to minimize the number of customer orders that have been started and are waiting to be completed. We describe a straightforward local search method together with a powerful lower bound based on a MIP formulation. Finally we introduce another MIP with specific cuts that ...

We address a class of planning problems where the optimization decisions influence the time of information discovery for a subset of the uncertain parameters. The standard stochastic programming approach cannot be used for these problems. We present a hybrid mixed-integer disjunctive programming formulation and a Lagrangean duality based branch and bound algorithm for these problems and illustr...

The primary aim of this paper is pedagogical. We first present and discuss a “wiring diagram” framework in order to elucidate the general links between economic growth and "natural capital." After developing the general framework, we develop parallel frameworks applicable to several specific sectors of the economy (agriculture, forestry, and manufacturing). Two appendices provide a mathematical...