Mechanistic models provide a powerful, minimally invasive tool for gaining a deeper understanding of the ecology of animals across geographic space and time. In this paper, we modified and validated the accuracy of the mechanistic model Niche Mapper for simulating heat exchanges of animals with counter-current heat exchange mechanisms in their legs and animals that wade in water. We then used N...

The Kinetoplastida are a diverse and globally distributed class of free-living and parasitic single-celled eukaryotes that collectively cause a significant burden on human health and welfare. In kinetoplastids individual genes do not have promoters, but rather all genes are arranged downstream of a small number of RNA polymerase II transcription initiation sites and are thus transcribed in poly...

Given a continuous function f : X → R and a cover I of its image by intervals, the Mapper is the nerve of a refinement of the pullback cover f−1(I). Despite its success in applications, little is known about the structure and stability of this construction from a theoretical point of view. As a pixelized version of the Reeb graph of f , it is expected to capture a subset of its features (branch...

We have developed a prototype authoring system for knowledge mapping that provides the capability to (a) specify map tasks (i.e., specify terms and links), (b) launch a knowledge map related to a task, (c) specify criterion or expert maps (for scoring purposes), (d) define groups of users and associate tasks to those groups, and (e) publish tasks for global access. The prototype interface is a ...

We present a software system solution that significantly simplifies data sharing of medical data. This system, called GEM (for the GAAIN Entity Mapper), harmonizes medical data. Harmonization is the process of unifying information across multiple disparate datasets needed to share and aggregate medical data. Specifically, our system automates the task of finding corresponding elements across di...

This paper presents a tool to automatically discover the network topol-ogy. The goal is to evaluate the performance of concurrent transfers (for example to improve collective communications) and not to discover the physical machines interconnection scheme (for administration purposes). The problems encountered, preliminary algorithms to solve them, as well as theoretical proofs of their validit...

Precision medicine is an emerging and important field for health care. Molecular tumor boards use a combination of clinical molecular data, such as somatic mutations to decide on personalized therapies patients who have run out standard treatment options. Personalized decisions require data from the hospital information system mutation be accessible in structured way. Here we introduce open pla...